The one health approach recognizes the interconnection between human, animal, and environmental health, emphasizing that human health should never be threatened in the pursuit of agricultural productivity. Indeed, within agricultural systems, this approach is particularly relevant, as the overuse of chemical inputs and the mismanagement of organic wastes can directly threaten human health. Overuse of chemical inputs can result in various health disturbances and contribute to the development of acute or chronic human diseases. Likewise, organic wastes constitute potential human health risks due to the presence of pathogens in these wastes such as bacteria, viruses, fungi, and parasites. Despite increasing research, many studies often lack integrated risk assessments of agrochemicals and organic waste within a “One Health” framework, leaving gaps in practical guidance for safe agricultural management. This review was conducted to address these gaps and answer the following questions: What are the human health risks associated with agrochemicals and mismanaged organic wastes? How can composting/compost mitigate these risks and support sustainable agricultural production? It examines the role of composting in managing organic wastes, producing high-quality compost, and reducing exposure to hazardous chemicals and pathogens. Furthermore, it outlines key characteristics of compost required to ensure safety for humans, plants, soil, and ecosystems. By integrating evidence on human health and crop productivity, this review provides insights for safe, sustainable agricultural practices within a unified One Health framework.