Amos B Smith III

Amos B Smith III


Research Focus & Metrics

Academic Career Length

36Years (1991-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
20 March 2015 in Journal of the American Chemical Society
Verified
Journal Article
Open access
SBStephen P. Brown
Stephen P. Brown
AIAmos B Smith III
Amos B Smith III
Protocols have been achieved that permit facile introduction of s-tetrazine into unprotected peptides and the protein, thioredoxin, between two cysteine sulfhydryl groups (i.e., staple), followed by photochemical release (i.e., unstaple) and regeneration of the peptide/protein upon removal of the cyano groups from the derived bisthiocyanate. The S,S-tetrazine macrocycles in turn provide a convenient handle for probe introduction by exploiting the inverse electron demand Diels–Alder reactivity of the tetrazine.

28 September 2012 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
CBCarlo Ballatore
Carlo Ballatore
KBKurt R. Brunden
Kurt R. Brunden
DHDonna M. Huryn
Donna M. Huryn
JTJohn Q. Trojanowski
John Q. Trojanowski
VLVirginia M.-Y. Lee
Virginia M.-Y. Lee
AIAmos B Smith III
Amos B Smith III

23 August 2002 in Journal of the American Chemical Society
Verified
Journal Article
Closed access
AIAmos B Smith III
Amos B Smith III
ISIgor G. Safonov
Igor G. Safonov
RCR. Michael Corbett
R. Michael Corbett

30 September 2008 in Chemical Communications
Verified
Journal Article
Closed access
PDF file
AIAmos B Smith III
Amos B Smith III
WWWilliam M. Wuest
William M. Wuest
Efficient construction of architecturally complex natural and unnatural products is the hallmark of organic chemistry. Anion relay chemistry (ARC)—a multi-component coupling protocol—has the potential to provide the chemist with a powerful synthetic tactic, enabling efficient, rapid elaboration of structurally complex scaffolds in a single operation with precise stereochemical control. The ARC tactic can be subdivided into two main classes, comprising the relay of negative charge either through bonds or through space, the latter with aid of a transfer agent. This review will present the current state of through-space anion relay, in conjunction with examples of natural and unnatural product syntheses that illustrate the utility of this synthetic method.

9 December 2013 in Journal of the American Chemical Society
Verified
Journal Article
Closed access
ASArtem Shvartsbart
Artem Shvartsbart
AIAmos B Smith III
Amos B Smith III