According to the requirement of high-performance development of modern ships, it is necessary to quickly and accurately predict the maneuverability of ships under wave conditions. In this paper, based on the CFD (Computational Fluid Dynamics) method in the commercial software STAR-CCM+, the numerical simulation of roll decay motion, pure heel motion, pure heave motion, and pure pitch motion of ship model 5415 is carried out. The relevant hydrodynamic derivatives are obtained, and the results are in good agreement with the experimental values. The equations of motion related to the heave and pitch motions are established according to the MMG (Maneuvering Motion Equation Research Group) model. Then, based on the above dynamic equations, the wave force module is added to successfully simulate and predict the pitch and heave responses of the ship under regular wave conditions, and it is concluded that the simulation model for rapid prediction is also applicable under waves.