As a promising non-invasive neuroimaging technique, functional near-infrared spectroscopy (fNIRS) has seen increasing use in neuroscientific studies over the last decades.^{1 – 3} Compared to other neuroimaging techniques, fNIRS has several specific advantages: acceptable spatial resolution; lower cost, silent, higher temporal resolution, lower sensitivity to head motion, and fewer physical constraints compared to functional magnetic resonance imaging (fMRI); portability/mobility and few restrictions on use location. These advantages make it an ideal alternative for detecting human brain activity in both healthy people (from newborns to the elderly) and patients with neurological or psychiatric conditions, in both laboratory and natural contexts. Validation studies using simultaneous fNIRS and fMRI scanning have shown fNIRS to be effective for both task-driven activation detection^{4 – 8} and resting-state brain function research.^9,10 FNIRS has been successfully applied to various neuroscience domains, including areas such as motor-related studies with large bodily movements, social cognitive neuroscience, and neurodevelopment.^{11 – 15} In addition to task-evoked activation studies, fNIRS has also seen increasing use in detecting spontaneous brain activity absent of external stimuli during resting state,^{16 – 20} which is particularly useful for several special populations who cannot perform complicated tasks, such as infants and patients with certain deficits.

The growing demand for advanced neural interfaces that enable precise brain monitoring and modulation has catalyzed significant research into flexible, biocompatible, and highly conductive materials. PEDOT:PSS-based bioelectronic materials exhibit high conductivity, mechanical flexibility, and biocompatibility, making them particularly suitable for integration into neural devices for brain science research. These materials facilitate high-resolution neural activity monitoring and provide precise electrical stimulation across diverse modalities. This review comprehensively examines recent advances in the development of PEDOT:PSS-based bioelectrodes for brain monitoring and modulation, with a focus on strategies to enhance their conductivity, biocompatibility, and long-term stability. Furthermore, it highlights the integration of multifunctional neural interfaces that enable synchronous stimulation-recording architectures, hybrid electro-optical stimulation modalities, and multimodal brain activity monitoring. These integrations enable fundamentally advancing the precision and clinical translatability of brain–computer interfaces. By addressing critical challenges related to efficacy, integration, safety, and clinical translation, this review identifies key opportunities for advancing next-generation neural devices. The insights presented are vital for guiding future research directions in the field and fostering the development of cutting-edge bioelectronic technologies for neuroscience and clinical applications.

Studying the neural basis of human social interactions is a key topic in the field of social neuroscience. Brain imaging studies in this field usually focus on the neural correlates of the social interactions between two participants. However, as the participant number further increases, even by a small amount, great difficulties raise. One challenge is how to concurrently scan all the interacting brains with high ecological validity, especially for a large number of participants. The other challenge is how to effectively model the complex group interaction behaviors emerging from the intricate neural information exchange among a group of socially organized people. Confronting these challenges, we propose a new approach called “Cluster Imaging of Multi-brain Networks” (CIMBN). CIMBN consists of two parts. The first part is a cluster imaging technique with high ecological validity based on multiple functional near-infrared spectroscopy (fNIRS) systems. Using this technique, we can easily extend the simultaneous imaging capacity of social neuroscience studies up to dozens of participants. The second part of CIMBN is a multi-brain network (MBN) modeling method based on graph theory. By taking each brain as a network node and the relationship between any two brains as a network edge, one can construct a network model for a group of interacting brains. The emergent group social behaviors can then be studied using the network’s properties, such as its topological structure and information exchange efficiency. Although there is still much work to do, as a general framework for hyperscanning and modeling a group of interacting brains, CIMBN can provide new insights into the neural correlates of group social interactions, and advance social neuroscience and social psychology.

A transcranial brain atlas is a new kind of brain atlas specialized for transcranial noninvasive brain stimulation/imaging techniques.

Emotion recognition based on neural signals is a promising technique for the detection of patients' emotions for enhancing healthcare. However, emotion-related neural signals, such as from functional near infrared spectroscopy (fNIRS), can be affected by various psychophysiological and environmental factors. There is a paucity of literature regarding data instability and classification instability in fNIRS-based emotion recognition systems, phenomenon which may lead to user dissatisfaction and abandonment. We collected data in an fNIRS-based 2-class emotion recognition test-retest experiment (3 week interval) with visual stimuli emotion induction to examine data instability and its impact on classification accuracy. We found a 22.2% average deterioration of emotion classification accuracy between the two sessions, suggesting that classification instability is a serious problem. We found that the changes in the distributions of the selected neural signal features, as evaluated by Kullback-Leibler (KL) divergence, were a likely cause of the accuracy decline. We analyzed the data instability and our results showed that instability of spatial activation patterns and instability of the hemodynamic response in the most activated region are correlated with accuracy decline. Finally, we propose a method for mitigating classification instability in fNIRS-based emotion recognition based on feature selection for stable features, the first such method to our knowledge. This new feature selection criterion considers not only the separability of features (evaluated by Fisher Score) but also their stability over time (evaluated by KL divergence between feature distributions at different time points). Testing showed that this method led to an approximately 5% improvement in cross-session generalization accuracy.

Objective. Growing evidence suggests that electroencephalography (EEG) electrode (sensor) potential time series (PTS) of slow cortical potentials (SCPs) hold motor neural correlates that can be used for motion trajectory prediction, commonly by multiple linear regression (mLR). It is not yet known whether arm-joint trajectories can be reliably decoded from current sources, computed from sensor data, from which brain areas they can be decoded and using which neural features. Approach. In this study, the PTS of 44 sensors were fed into sLORETA source localization software to compute current source activity in 30 regions of interest (ROIs) found in a recent meta-analysis to be engaged in action execution, motor imagery and motor preparation. The current sources PTS and band-power time series (BTS) in several frequency bands and time lags were used to predict actual and imagined trajectories in 3D space of the three velocity components of the hand, elbow and shoulder of nine subjects using an mLR model. Main results. For all arm joints and movement types, current source SCPs PTS contributed most to trajectory reconstruction with time lags 150, 116 and 84 ms providing the highest contribution, and current source BTS in any of the tested frequency bands was not informative. Person’s correlation coefficient (r) averaged across movement types, arm joints and velocity components using source data was slightly lower than using sensor data (r = 0.25 and r = 0.28, respectively). For each ROI, the three current source dipoles had different contribution to the reconstruction of each of the three velocity components. Significance. Overall, our results demonstrate the feasibility of predicting of actual and imagined 3D trajectories of all arm joints from current sources, computed from scalp EEG. These findings may be used by developers of a future BCI as a validated set of contributing ROIs.