This study designed, techno-economically analyzed and compared the heat-assisted extraction (HAE)- and ultrasound-assisted extraction (UAE)-technology-based processes (HAE-tBP and UAE-tBP) for the production of crude anthocyanins powder (CAnysP) from Hibiscus sabdariffa calyx (HSC) with the assistance of SuperPro Designer software. Both the base cases and industrial setups of 600 L extractor capacities for HAE- and UAE-tBPs were analyzed and compared. When building the process flowsheets, peculiarities of the technicalities of both HAE and UAE extractors were taken into consideration. Materials and energy demands, production costs and unit production cost (UPC) of CAnysP were the parameters used for process analysis. Uncertainty and sensitivity analyses were conducted for the process with least CAnysP UPC using Monte Carlo simulations in Oracle Crystal Ball software. The HAE-tBP recorded the highest number of batches of 5278 per annum. HSC of 15.551 kg was required to produce 7.433 and 10.022 kg/batch CAnysP by 600 L extractor setup of HAE- and UAE-tBPs, respectively. The UAE-tBP achieved lower CAnysP UPC (164.28 US$/kg) compared with HAE-tBP (176.31 US$/kg) with 80.08% certainty. Out of the variables considered for sensitivity analysis of UAE-tBP UPC, ultrasound treatment time contributed the highest (+62%), while anthocyanins recovery contributed the least (+0.2%) to the variance in UPC.