My laboratory has been investigating the adverse effects of hexavalent chromium (Cr(VI) on female reproduction and fetal development. Cr(VI) is a heavy metal endocrine-disrupting chemicals (EDCs). The exponential increase in Cr(VI) use by more than 50 industries and improper disposal of Cr(VI) waste have led to serious contamination of soil, air, and water with Cr(VI). Our laboratory has set goals to understand the adverse health effects and mechanisms of Cr(VI) on the development and functions of the female reproductive system and fetal and placental development. Strikingly, women who are occupationally and environmentally exposed to Cr(VI) experience infertility or subfertility, early abortions, pre-term birth, stillbirth, and birth defects in children. Our previous findings reported placental pathogenesis due to increased apoptosis and oxidative stress in trophoblast cells with Cr(VI) exposure. Our laboratory has established Cr(VI) as a potent female reproductive toxicant, adversely affecting ovarian germ cells and trophoblasts through p53 and oxidative stress-mediated mechanisms. Our research is also focused on understanding how Cr(VI) causes abnormal vascular adaptation to pregnancy by altering uterine artery remodeling using environmentally relevant doses of Cr(VI). I have a solid and consistent history of obtaining NIH funding in female reproductive and developmental toxicology over the past fourteen years.