Prof. Walter Kolch
University College Dublin, Systems Biology Ireland, School fo Medicine, Belfield Dublin 4, Ireland
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Academic Career Length
39Years (1988-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications14 May 2007 in Oncogene
Journal Article
Cancer can be perceived as a disease of communication between and within cells. The aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature prominently. Here, we discuss recent findings and hypotheses on the role of MAPK pathways in cancer. Cancerous mutations in MAPK pathways are frequently mostly affecting Ras and B-Raf in the extracellular signal-regulated kinase pathway. Stress-activated pathways, such as Jun N-terminal kinase and p38, largely seem to counteract malignant transformation. The balance and integration between these signals may widely vary in different tumours, but are important for the outcome and the sensitivity to drug therapy.
1 July 1993 in Nature
Journal Article
Walter KolchGHGisela Heidecker
Gisela Heidecker
GKGeorg Kochs
Georg Kochs
RHRichard Hummel
Richard Hummel
HVHaleh Vahidi
Haleh Vahidi
URUlf R. Rapp
Ulf R. Rapp
+3
1 September 1999 in Nature
Journal Article
KYKam Yeung
Kam Yeung
TSThomas Seitz
Thomas Seitz
SLShengfeng Li
Shengfeng Li
PJPetra Janosch
Petra Janosch
BMBrian McFerran
Brian McFerran
Walter Kolch +6
Journal Article
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role of MAPK pathways in modulating drug sensitivity and resistance in cancer. We briefly discuss new findings in the extracellular signaling-regulated kinase (ERK) pathway, but mainly focus on the mechanisms how stress activated MAPK pathways, such as p38 MAPK and the Jun N-terminal kinases (JNK), impact the response of cancer cells to chemotherapies and targeted therapies. In this context, we also discuss the role of metabolic and epigenetic aberrations and new therapeutic opportunities arising from these changes.
1 June 2010 in Nature Reviews Molecular Cell Biology
Journal Article
About Me
Prof. Walter Kolch is the Director
of Systems Biology Ireland at the School of Medicine, University College Dublin.
He was a Professor
of Molecular Cell Biology from 2000 to 2009 and Director of Sir Henry Wellcome
Functional Genomics Facility from 2001 to 2009 at the University
of Glasgow. He graduated with a Doctor of Medicine from the University
of Vienna in Austria. A leading international proponent of precision medicine, he
originally trained as a clinician, subsequently working in the pharmaceutical
industry, research institutes, and academia. He has designed, developed, and
coordinated innovative systems biology, systems medicine, and precision
medicine programs of vision, scale, and impact with a track record of
competitive grant funding of over two hundred million. He serves on several
editorial boards and scientific advisory boards and is a Fellow of the Royal
Society of Edinburgh and a Member of the Royal Irish Academy. In 2022, he received
the prestigious Science Foundation Ireland Mentorship Award.