Additive manufacturing (AM) is a rapidly evolving technology that enables the fabrication of complex 3D components across a wide range of materials and applications. Among various AM techniques, direct energy deposition (DED) has gained significant attention for its ability to produce metal and alloy components with moderate geometric complexity while maintaining a high deposition rate. This makes DED particularly suitable for real-world applications, including in-situ repair and restoration of metallic parts. Due to the nature of the DED process, components undergo extreme heating and cooling cycles, leading to microstructural evolution, process-induced defects, and variations in properties. While extensive research has explored the microstructure and mechanical properties of DED-fabricated alloys, studies on their surface degradation remain incomplete. Corrosion behavior has been well documented, given its significance in AM alloys; however, their tribological performance remains largely unexplored. This paper provides a comprehensive review of the wear behavior of DED-manufactured alloys, emphasizing the potential of DED technology for producing durable components. Specifically, it examines the wear characteristics of four key material groups—Fe-based, Ni-based, Ti-based, and Cu-based alloys—by summarizing existing studies and analyzing the underlying mechanisms influencing their wear resistance. Finally, the paper identifies research gaps and outlines future directions to advance the understanding of wear performance in DED alloys, paving the way for further innovation in this field.