Christopher Gordon

Dr. Christopher Gordon

orcid

Research Focus & Metrics

Academic Career Length

23Years (2004-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
1 November 2018 in Coordination Chemistry Reviews
Verified
Journal Article
Closed access
KDKrishant M. Deo
Krishant M. Deo
DADale Ang
Dale Ang
Brondwyn Sarah McGhieBrondwyn Sarah McGhie
Brondwyn Sarah McGhie
ARAdeline Rajamanickam
Adeline Rajamanickam
ADAnkita Dhiman
Ankita Dhiman
Janice Rae Aldrich-WrightJanice Rae Aldrich-Wright
Janice Rae Aldrich-Wright

21 May 2009 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
THTimothy A. Hill
Timothy A. Hill
CGChristopher Gordon
Christopher Gordon
AMAndrew B. McGeachie
Andrew B. McGeachie
BVBarbara Venn-Brown
Barbara Venn-Brown
LOLuke R. Odell
Luke R. Odell
AMAdam Mccluskey
Adam Mccluskey

22 January 2013 in Journal of Medicinal Chemistry
Verified
Journal Article
Open access
CGChristopher Gordon
Christopher Gordon
PWPaul Williams
Paul Williams
WCWeng C. Chan
Weng C. Chan
Virulence gene expression in Staphylococcus aureus is tightly regulated by intricate networks of transcriptional regulators and two-component signal transduction systems. There is now an emerging body of evidence to suggest that the blockade of S. aureus virulence gene expression significantly attenuates infection in experimental models. In this Perspective, we will provide insights into medicinal chemistry strategies for the development of chemical reagents that have the capacity to inhibit staphylococcal virulence expression. These reagents can be broadly grouped into four categories: (1) competitive inhibitors of the accessory gene regulator (agr) quorum sensing system, (2) inhibitors of AgrA–DNA interactions, (3) RNAIII transcription inhibitors, and (4) inhibitors of the SarA family of transcriptional regulators. We discuss the potential of specific examples of antivirulence agents for the management and treatment of staphylococcal infections.

9 June 2015 in Organic & Biomolecular Chemistry
Verified
Journal Article
Closed access
PDF file
PCPeter J. Cossar
Peter J. Cossar
LHLacey Hizartzidis
Lacey Hizartzidis
Michela SimoneMichela Simone
Michela Simone
AMAdam Mccluskey
Adam Mccluskey
CGChristopher Gordon
Christopher Gordon
There has been an increasing body of evidence that flow hydrogenation enhances reduction outcomes across a wide range of synthetic transformations. Moreover flow reactors enhance laboratory safety with pyrophoric catalysts contained in sealed cartridges and hydrogen generated in situ from water. This mini-review focuses on recent applications of flow chemistry to mediate nitro, imine, nitrile, amide, azide, and azo reductions. Methodologies to effect de-aromatisation, hydrodehalogenation, in addition to olefin, alkyne, carbonyl, and benzyl reductions are also examined. Further, protocols to effect chemoselective reductions and enantioselective reductions are highlighted. Together these applications demonstrate the numerous advantages of performing hydrogenation under flow conditions which include enhanced reaction throughput, yields, simplified workup, and the potential applicability to multistep and cascade synthetic protocols.

9 December 2004 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
CGChristopher Gordon
Christopher Gordon
PKPaul Keller
Paul Keller

14 August 2007 in Synthetic Communications
Verified
Journal Article
Closed access
AGAllan B. Gamble
Allan B. Gamble
JGJames Garner
James Garner
CGChristopher Gordon
Christopher Gordon
SOSean M. J. O'COnner
Sean M. J. O'COnner
PKPaul Keller
Paul Keller
The selective reduction of aryl nitro compounds in the presence of sensitive functionalities, including halide, carbonyl, nitrile, and ester substituents, under ultrasonic irradiation at 35 kHz is reported in yields of 39–98%. Iron powder proved superior to stannous chloride with high tolerance of sensitive functional groups and high yields of the desired aryl amines in relatively short reaction times. Simple experimental procedure and purification also make the iron reduction of aryl nitro compounds advantageous over other methods of reduction.