Objectives: This cohort study examines the relationship between quality of life and oral health in adolescents and young adults in the Zagreb area. Methods: The research involved 250 participants aged 14 to 25 from Zagreb. Each participant was examined by an oral medicine doctor using a probe and mirror in a dental unit, and their DMFT (Decayed, Missing, and Filled Teeth) status was determined. Participants also completed questionnaires on their socio-economic status (SES) and the impact of their oral health on quality of life (OHIP-14, Oral Health Impact Profile). Results: Caries was the most common dental issue among adolescents (2.23 ± 2.58), with restoration being the most frequent treatment (54%). Endodontic treatment and tooth extraction were more prevalent among individuals with lower SES (24.1%), who also had worse DMFT scores (8.09 ± 5.56). Prophylaxis was equally distributed across SES and gender. Male patients had more carious teeth (2.75 ± 3.07) than female patients (1.85 ± 2.08), while female patients scored worse on the OHIP-14 scale (10.97 ± 8.77) compared to males (8.81 ± 8.11). Age positively correlated with both OHIP-14 and DMFT scores. Conclusions: Adolescents and young adults in Zagreb, Croatia, exhibited high DMFT and OHIP-14 scores, reflecting significant oral health issues and reduced quality of life, particularly among older individuals and those with lower SES. The association between invasive treatments (e.g., endodontic procedures and extractions) and diminished quality of life underscores the necessity for early preventive measures, including regular dental check-ups and targeted oral health education.

Phosphorylated inositol hexaphosphate (IP6) is a naturally occurring carbohydrate, and its parent compound, myoinositol (Ins), is abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate essential cellular functions. IP6 has profound modulation effects on macrophages, which warrants further research on the therapeutic benefits of IP6 for inflammatory diseases. Here, we review IP6 as a promising compound that has the potential to be used in various areas of dentistry, including endodontics, restorative dentistry, implantology, and oral hygiene products, due to its unique structure and characteristic properties. Available as a dietary supplement, IP6 + Ins has been shown to enhance the anti-inflammatory effect associated with preventing and suppressing the progression of chronic dental inflammatory diseases. IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights into future use of IP6 in the fields of orthodontics, periodontics, implants, and pediatric dentistry.