This study leveraged the social exchange theory to explore the influence of the knowledge management cycle on employee engagement, job satisfaction, and organizational culture within the Ghana Highway Authority (GHA). The structural equation modeling (SEM) software (AMOS version 23) was employed to analyze data from 300 GHA employees. The study used snowball sampling and a descriptive cross-sectional methodology to collect data through printed and electronic questionnaires. The findings demonstrated a substantial and positive impact of the knowledge management cycle on employee engagement, job satisfaction, and organizational commitment. Employee engagement also exhibited a significant and positive influence on both job satisfaction and organizational commitment. Furthermore, employee engagement partially mediated the relationships between the knowledge management cycle, job satisfaction, and organizational commitment. This study’s findings underscore the practical implications of allocating resources to knowledge management activities. Such allocation can promote organizational culture and employee satisfaction, enabling firms to achieve real gains.