Dengue virus 2 (DENV-2) seriously contributes to dengue-related mortality. It includes five nonsylvatic genotypes, with cosmopolitan being the most widespread with a significant contribution to the total number of DENV-2 cases globally. In South America, the cosmopolitan genotype was first recorded in 2019 in Madre de Dios, Peru, and then in Goiás (Midwest Brazil) in November 2021. In this study, we tested 163 human serum samples from Acre (Northern Brazil) collected during a DENV outbreak between 2020 and 2021 for all DENV genotypes by RT-qPCR. Of the 163 samples, 139 were positive for DENV-2, and 5 were positive for DENV-1. Five DENV-2-positive samples from early 2021 were sequenced, and the sequences clustered with the three other DENV-2 cosmopolitan genotype sequences already recorded on the continent. These results create a geographical link, suggesting the possible route of introduction of the DENV-2 cosmopolitan genotype into Brazil through the border with Peru, from which it may have dispersed to Midwest Brazil.

Objetivo: Descrever por meio de uma revisão integrativa o perfil do Biomédico Esteta e a segurança do paciente em procedimentos estéticos. Métodos: Trata-se de um estudo de revisão integrativa sobre o papel do Biomédico Esteta e a segurança do paciente em procedimentos estéticos. O estudo foi realizado a partir da busca por artigos disponibilizados pelas plataformas: Pubmed, SCIELO e Portal Capes, a pesquisa priorizou textos em português e inglês e documentos das resoluções do Conselho Regional e Federal de Biomedicina. Após a seleção dos critérios de inclusão e exclusão, 7 artigos foram selecionados para análise íntegra. Resultados: Foi possível observar que relação entre os procedimentos aderidos às boas práticas de segurança do paciente e o conhecimento das técnicas pelos biomédicos, proporcionam um resultado seguro nos tratamentos estéticos e, embora ainda não existam protocolos específicos segundo a OMS para os procedimentos estéticos, nota-se que o risco de complicações e intercorrências durante ou após os procedimentos são baixos desde que haja o acompanhamento correto. Considerações finais: Diante disso, foi possível estabelecer anotável a necessidade pela contribuição com a segurança do paciente e os cuidados paliativos acercados procedimentos estéticos de modo a possibilitar uma boa resposta terapêutica.

The aim of this study was to carry out a literature review on iron deficiency anemia, with an emphasis on the correlation between nutritional deficiency and related factors. Using the Scielo, PubMed, Academic Google and VHL databases, in Portuguese, English and Spanish, using the following inclusion criteria: publications made in January 2010 until 2021, which correspond to the proposed objectives, highlighting the diagnosis, treatment and the prevention of iron deficiency anemia and the following exclusion criteria: published prior to 2010 and not meeting the objectives. Nineteen articles were selected that fit the desired objectives. Through the research carried out, it was possible to conclude that iron deficiency anemia is considered the most common of anemia, and can be cited as a serious public health problem, with main emphasis in developing countries. In addition, it can be seen that iron deficiency anemia is caused by several factors that can be internal and external, where any symptom, whether specific or not needing to be analyzed, requires that a detailed diagnosis be made, that its treatment be complete and accompanied by a professional in the area and that prevention methods are passed on to society and thus prevent individuals from suffering from this condition.

Arboviruses transmitted by Aedes aegypti cause high number of cases and deaths annually. The aim was to investigate the presence of the presence of Dengue (DENV), Zika (ZIKV) and Chikungunya (CHIKV) viruses in endemic areas of Maranhão, northeastern Brazil. The study was carried out in Caxias, Codó, Peritoró, and São Mateus do Maranhão in 2019 (Caxias) and 2022. The blood samples were subjected to RNA extraction and then tested by RT-qPCR. Cell culture was used to attempt viral isolation and subsequent sequencing. In total, 171 samples were analyzed (32 from 2019, 18.7%) and 72 (42.1%) were found to have arboviruses: 68 (39.7%) from Caxias; 2 (1.1%) from Codó; 1 (0.6%) from Peritoró; and 1 (0.6%) from São Mateus. Overall, 85.3% (n = 58) of the positive samples were infected with DENV-1, 4 (four) (5.9%) with DENV-2 (Caxias), 1 (one) (1.5%) with DENV-3 (Caxias), and in 6 (six) (7.3%) samples CHIKV was detected, with one co-infection of DENV-1 and CHIKV (Caxias). The DENV-1 genotype V and the ECSA genotype of CHIKV were characterized in samples from Caxias. The detection of DENV-1, DENV-2, DENV-3, and more CHIKV in the interior of Maranhão alerts to the importance of virological studies in these areas.

We hypothesize the possible route of introduction of the cosmopolitan DENV-2 genotype into Brazil through the border with Peru. The five sequences presented in this study create a geographical link with the three others sequences of this genotype already recorded on the continent.

Objetivou-se realizar uma análise do número de casos notificados do vírus da raiva humana na região Norte do Brasil no período de 2000 a 2019. Trata-se de estudo observacional, de base epidemiológica, com base em dados do SINAN no período de 2000 a 2019. Foram elaborados mapas e gráficos para análise espacial do número de casos. Observou-se, no período de 2000 a 2006, 61 casos. Sendo que, nos anos de 2004 e 2005 ocorreram alguns surtos. No período de 2006 a 2015 não houveram notificações. Já nos anos de 2016 a 2019 foram notificados 16 casos. De 2000 a 2019 foram registrados 316 casos no país. A região Nordeste obteve maior número de casos no Brasil no período estudado (N=204; 65%), em seguida a região Norte (N=77; 24%). Assim, a otimização do controle da doença, pela adoção de recursos regulatórios, destaca-se como a melhor medida para o controle da raiva.