Nikola Bošković

Dr. Nikola Bošković

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Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 February 2017 in IEEE Transactions on Antennas and Propagation
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Journal Article
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NBNikola Bošković
Nikola Bošković
BJBranka Jokanovic
Branka Jokanovic
MRMilos Radovanovic
Milos Radovanovic
This paper presents a novel design of the 1-D frequency scanning antenna array with enhanced scan sector, frequency sensitivity, and sidelobe suppression. The antenna is intended for the direct imaging radar sensors. Modified pentagonal dipoles with impedances ranging from 120 to 1070 Ω are used as radiating elements to provide the required sidelobe suppression. For the antenna design, new types of phase shifters are considered, with respect to their insertion loss, frequency bandwidth, phase shift, and manufacturing simplicity: the double-cell left-handed shifter and its right-handed counterpart. Four linear arrays with eight pentagonal dipoles are combined to obtain the antenna array with higher gain and narrower main beam with respect to constituent linear arrays, but with almost identical H-plane scanning properties. The proposed antenna array was manufactured, and the measured results show an increased scan sector of 55°, high frequency sensitivity of 14.25°/100 MHz, gain of 15.5-17 dBi, and low sidelobe levels of around -20 dB in the whole scanning frequency range. Measured results are in very good agreement with simulations.

5 November 2022 in Bioengineering
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Journal Article
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MRMarija Radmilovic-Radjenovic
Marija Radmilovic-Radjenovic
NBNikola Bošković
Nikola Bošković
BRBranislav M. Radjenovic
Branislav M. Radjenovic
Microwave ablation is recognized as a minimally invasive, fast-recovery treatment for destroying cancer cells using the heat generated by microwave energy. Despite the unquestionable benefits of microwave ablation, the interaction of the microwave applicator with the tissue may result in localized heating and damage to the surrounding tissue. The majority of the tissue damage can be removed by clarifying the conditions for their development. In addition to experimental methods, computer modeling has proven to be an effective tool for optimizing the performance of microwave ablation. Furthermore, because the thermal spread in biological tissue is difficult to measure, developing a predictive model from procedural planning to execution may have a substantial influence on patient care. The comprehension of heat transport in biological tissues plays a significant role in gaining insight into the mechanisms underlying microwave ablation. Numerical methods that enable ablation size control are required to guarantee tumor destruction and minimize damage to healthy tissues. Various values of input power and ablation time correspond to different tumor shapes ensuring the preservation of healthy tissues. The optimal conditions can be estimated by performing full three-dimensional simulations. This topical review recapitulates numerous computational studies on microwave tumor ablation. Novel areas emerging in treatment planning that exploit the advantages of numerical methods are also discussed. As an illustration, the results of the three-dimensional simulations of real liver tumors in the 3D-IRCADb-01 database are presented and analyzed. The simulation results confirm that numerical methods are very useful tools for modeling microwave tumor ablation with minimal invasiveness and collateral damage.

8 October 2018 in IEEE Transactions on Antennas and Propagation
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Journal Article
Closed access
NBNikola Bošković
Nikola Bošković
BJBranka Jokanovic
Branka Jokanovic
MRMiloš M. Radovanović
Miloš M. Radovanović
NDNebojsa Doncov
Nebojsa Doncov
In this work, a novel design of patch antenna with two symmetrical slits and two closely spaced resonances is proposed. Novel patch antenna demonstrates a great flexibility in impedances adjustment at both resonances that is of a great importance in the design of series fed antenna arrays with a large number of radiating elements. Printed antenna with two linear arrays consisting of 16 serially fed patches is designed and fabricated. Measured results agree very well with simulations. Antenna operation frequency range is 15.6–17.3 GHz that is 10.3% of a relative bandwidth. The measured antenna gain is 19.5 dBi with a small variation of 1.2 dB within the whole operating bandwidth, sidelobe levels are below −22 dB in H-plane and −11.5 dB in E-plane. Half power beamwidth is less than 8° and 40°, in H-and E-planes, respectively. Antenna array exhibits the enhanced impedance and radiation bandwidth in comparison with similar antenna structures and is very suitable for various radar applications, notably for compact, low-cost frequency-modulated continuous wave systems.

1 July 2022 in Biomedicines
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Journal Article
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MRMarija Radmilovic-Radjenovic
Marija Radmilovic-Radjenovic
NBNikola Bošković
Nikola Bošković
MSMartin Sabo
Martin Sabo
BRBranislav M. Radjenovic
Branislav M. Radjenovic
Simulation techniques are powerful tools for determining the optimal conditions necessary for microwave ablation to be efficient and safe for treating liver tumors. Owing to the complexity and computational resource consumption, most of the existing numerical models are two-dimensional axisymmetric models that emulate actual three-dimensional cancers and the surrounding tissue, which is often far from reality. Different tumor shapes and sizes require different input powers and ablation times to ensure the preservation of healthy tissues that can be determined only by the full three-dimensional simulations. This study aimed to tailor microwave ablation therapeutic conditions for complete tumor ablation with an adequate safety margin, while avoiding injury to the surrounding healthy tissue. Three-dimensional simulations were performed for a multi-slot microwave antenna immersed in two tumors obtained from the 3D-IRCADb-01 liver tumors database. The temperature dependence of the dielectric and thermal properties of healthy and tumoral liver tissues, blood perfusion, and water content are crucial for calculating the correct ablation time and, thereby, the correct ablation process. The developed three-dimensional simulation model may help practitioners in planning patient-individual procedures by determining the optimal input power and duration of the ablation process for the actual shape of the tumor. With proper input power, necrotic tissue is placed mainly in the tumor, and only a small amount of surrounding tissue is damaged.

10 June 2023 in Mathematics
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Journal Article
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NBNikola Bošković
Nikola Bošković
MRMarija Radmilovic-Radjenovic
Marija Radmilovic-Radjenovic
BRBranislav M. Radjenovic
Branislav M. Radjenovic
Microwave ablation is a procedure for treating various types of cancers during which a small needle-like probe is inserted inside the tumor, which delivers microwave energy, causes tissue heating, and effectively produces necrosis of the tumor tissue. Mathematical models of microwave ablation involve the modeling of multiple physical phenomena that occur during the procedure, including electromagnetic wave propagation, heat transfer, and tissue damage. In this study, a complete model of a microwave ablation procedure based on open-source software components is presented. First, the comprehensive procedure of mesh creation for the complete geometric arrangement of the microwave ablation, including a multi-slot coaxial antenna, a real liver tumor taken from the database, and the surrounding liver tissue, is described. It is demonstrated that utilizing smart meshing procedures significantly reduces the usage of computational resources and simulation time. An accurate custom explicit Euler time loop was designed to obtain temperature values and estimate tissue necrosis across the computational domain during the time of microwave ablation. The simulation results obtained by solving the electromagnetic field using the finite element method in the frequency domain are presented and analyzed. The simulation was performed for a microwave frequency of 2.45 GHz, and the volumetric distribution of temperature and estimation of cell damage over 600 s are presented.

11 November 2024 in Bioengineering
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Journal Article
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NBNikola Bošković
Nikola Bošković
SNSrdjan Nikolic
Srdjan Nikolic
BRBranislav M. Radjenovic
Branislav M. Radjenovic
MRMarija Radmilovic-Radjenovic
Marija Radmilovic-Radjenovic
Microwave ablation is becoming a standard procedure for treating tumors based on heat generation, causing an elevation in the tissue temperature level from 50 to 60 °C, causing tissue death. Microwave ablation is associated with uniform cell killing within ablation zones, multiple-antenna capability, low complication rates, and long-term survival. Several reports have demonstrated that multiple-antenna microwave ablation is a promising strategy for safely, rapidly, and effectively treating large tumors. The key advantage of multi-antenna tumor microwave ablation is the creation of a large, well-defined ablation zone without excessively long treatment times or high power that can damage healthy tissue. The strategic positioning of multiple probes provides a fully ablated volume, even in regions where individual probe damage is incomplete. Accurate modeling of the complex thermal and electromagnetic behaviors of tissue is critical for optimizing microwave ablation because material parameters and tissue responses can change significantly during the procedure. In the case of multi-antenna microwave ablation, the calculation complexity increases significantly, requiring significant computational resources and time. This study aimed to evaluate the efficacy and safety of liver percutaneous microwave ablation using the simultaneous activation of three antennas for the treatment of lesions larger than 3 cm. Based on the known results from a single-probe setup, researchers can estimate and evaluate various spatial configurations of the three-probe array to identify the optimal arrangement. Due to the synergistic effects of the combined radiation from the three antennas, the resulting ablation zone can be significantly larger, leading to better outcomes in terms of treatment time and effectiveness. The obtained results revealed that volumetric damage and the amount of damaged healthy tissue are smaller for a three-antenna configuration than for microwave ablation using a single-antenna and two-antenna configurations.