Incorporating technology into virtual education encourages educational institutions to demand a migration from the current learning management system towards an intelligent virtual educational system, seeking greater benefit by exploiting the data generated by students in their day-to-day activities. Therefore, the design of these intelligent systems must be performed from a new perspective, which will take advantage of the new analytical functions provided by technologies such as artificial intelligence, big data, educational data mining techniques, and web analytics. This paper focuses on primary education in developing countries, showing the design of an intelligent virtual educational system to improve the efficiency of primary education through recommendations based on reliable data. The intelligent system is formed of four subsystems: data warehousing, analytical data processing, monitoring process and recommender system for educational agents. To illustrate this, the paper contains two dashboards that analyze, respectively, the digital resources usage time and an aggregate profile of teachers’ digital skills, in order to infer new activities that improve efficiency. These intelligent virtual educational systems focus the teaching–learning process on new forms of interaction on an educational future oriented to personalized teaching for the students, and new evaluation and teaching processes for each professor.

Modern genomic technologies allow us to perform genome-wide analysis to find gene markers associated with the risk and survival in cancer patients. Accurate risk prediction and patient stratification based on robust gene signatures is a key path forward in personalized treatment and precision medicine. Several authors have proposed the identification of gene signatures to assign risk in patients with breast cancer (BRCA), and some of these signatures have been implemented within commercial platforms in the clinic, such as Oncotype and Prosigna. However, these platforms are black boxes in which the influence of selected genes as survival markers is unclear and where the risk scores provided cannot be clearly related to the standard clinicopathological tumor markers obtained by immunohistochemistry (IHC), which guide clinical and therapeutic decisions in breast cancer. Here, we present a framework to discover a robust list of gene expression markers associated with survival that can be biologically interpreted in terms of the three main biomolecular factors (IHC clinical markers: ER, PR and HER2) that define clinical outcome in BRCA. To test and ensure the reproducibility of the results, we compiled and analyzed two independent datasets with a large number of tumor samples (1024 and 879) that include full genome-wide expression profiles and survival data. Using these two cohorts, we obtained a robust subset of gene survival markers that correlate well with the major IHC clinical markers used in breast cancer. The geneset of survival markers that we identify (which includes 34 genes) significantly improves the risk prediction provided by the genesets included in the commercial platforms: Oncotype (16 genes) and Prosigna (50 genes, i.e. PAM50). Furthermore, some of the genes identified have recently been proposed in the literature as new prognostic markers and may deserve more attention in current clinical trials to improve breast cancer risk prediction. All data integrated and analyzed in this research will be available on GitHub (https://github.com/jdelasrivas-lab/breastcancersurvsign), including the R scripts and protocols used for the analyses. Supplementary data are available at Bioinformatics Advances online.

Presentación oral, parte del suplemento: Highlights from the Third International Society for Computational Biology (ISCB) Student Council Symposium at the Fifteenth Annual International Conference on Intelligent\ud Systems for Molecular Biology (ISMB)\ud Vienna, Austria. 21 July 2007.DNA Microarrays allow us to monitor the expression level\ud of thousands of genes simultaneously across a collection\ud of related samples. This technology has been applied to\ud the prediction of cancer considering the gene expression\ud profiles in both, normal and cancer samples.Peer reviewe

Los cambios producidos en los últimos años en cuanto a modelos de comunicación social han llevado a todos los sectores a adaptarse a los nuevos medios para alcanzar a su público. La comunicación de la ciencia no es una excepción. La manera en que se distribuyen contenidos sobre ciencia está cambiando debido a la presencia creciente de tecnologías, y la red social Twitter se ha convertido en un importante aliado debido a su gran volumen de usuarios. En el presente trabajo, se utilizan técnicas de aprendizaje automático para desarrollar un clasificador —que funciona en tiempo real— de sentimiento relacionados con mensajes publicados en Twitter. Para ello, se descargaron 200 000 tweets destinados a construir un corpus de entrenamiento limpio y procesado de 10 000 textos etiquetados, la mitad positivos y la mitad negativos, sobre ciencia en español. El corpus permite entrenar el modelo de aprendizaje automático y construir un prototipo OpScience, capaz de determinar el sentimiento de mensajes publicados en Twitter en tiempo real. Los resultados relacionados con la exactitud del clasificador corresponden al 72 %. Estos resultados pueden ayudar a darle mayor valor a temas de la comunicación científica en un espacio de debate social y predecir intereses o tendencias futuras, como se pudo comprobar en una prueba en enero de 2019.