Dolores de la Mata

Prof. Dr. Dolores de la Mata

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 June 2023 in JCO Global Oncology
Verified
Journal Article
Open access
RVRaymond B. Mailhot Vega
Raymond B. Mailhot Vega
BRBeatriz E. Garcia Robles
Beatriz E. Garcia Robles
CMChristopher G. Morris
Christopher G. Morris
KBKara Buss
Kara Buss
UMUlises Mejia
Ulises Mejia
DMDolores de la Mata
Dolores de la Mata
PURPOSE: Mexico and Central America have the highest childhood cancer incidence in the West. Pediatric-specific oncology knowledge contributes to the disparity. We sought to (1) determine the self-identified treatment patterns and needs of Mexican pediatric radiation oncologists and (2) pilot a workshop to improve contouring accuracy. MATERIALS AND METHODS: Partnering with local experts and the Sociedad Mexicana de Radioterapeutas (SOMERA), a 35-question survey was designed to ascertain pediatric radiotherapy capacity and distributed through the SOMERA listserv. The most challenging malignancies were selected for workshop. Participants received precontouring and postcontouring homework to assess improvement per the Dice metric. The Wilcoxon sign-rank test was used for comparative statistics. RESULTS: Ninety-four radiation oncologists attempted and 79 completed the survey. Forty-four (76%) felt comfortable treating a pediatric patient, and 36 (62%) were familiar with national protocols for pediatric treatment. Most had access to nutrition, rehabilitation, endocrinology, and anesthesia; 14% had access to fertility services and 27% to neurocognitive support; 11% noted no support, and only one respondent had child-life support. The postsurvey contouring workshop was conducted for high-grade glioma, medulloblastoma, and Hodgkin lymphoma. Significant improvements were seen in all target volumes. CONCLUSION: We present the first national survey of Mexico's pediatric radiotherapy capacity and Latin American e-contouring educational intervention with preworkshop and postworkshop Dice metrics, noting statistically significant improvement in all target volumes. Participation improved compared with prior experience through SOMERA partnership and Continuing Medical Education incentivization.

1 January 2024 in International Journal of Breast Cancer
Verified
Journal Article
Open access
DMDolores de la Mata
Dolores de la Mata
BSBernardino Gabriel Santiago-Concha
Bernardino Gabriel Santiago-Concha
JRJUAN ENRIQUE BARGALLO ROCHA
JUAN ENRIQUE BARGALLO ROCHA
CRCarlos Daniel Robles-Vidal
Carlos Daniel Robles-Vidal
DGDaniella Gómez-Pue
Daniella Gómez-Pue
AMAntonio Maffuz-Aziz
Antonio Maffuz-Aziz
Purpose: This study is aimed at investigating the 10‐year outcomes of intraoperative radiotherapy (IORT) in Mexican women with early breast cancer (EBC) treated at the Centro Medico ABC, Mexico City.Methods: A cohort study included women with early‐stage invasive ductal carcinoma aged ≥ 45 years without prior oncologic treatment, tumor size ≤ 3.5 cm, cN0M0, positive hormone receptors, margins ≥ 2 mm, negative sentinel lymph nodes, and no extensive lymphovascular invasion. IORT was administered at 20 Gy for 20–30 min after a lumpectomy. Follow‐up extended over 10 years and included clinical examinations every 6 months for the first 18 months, followed by annual mammograms and conventional examinations. Patients out of the criteria were excluded from this study because they were referred for additional surgery and/or whole‐breast radiation therapy.Results: The study involved 238 patients with an average age of 61.1 years. The mean tumor size was 12 mm, and the percentages of lymphatic invasion, positive hormone receptors, and HER2/neu overexpression were 12.6%, 90.8%, and 2.1%, respectively. The median follow‐up was 66.6 months (range: 1–126 months), and the overall survival and mastectomy‐free rate reached 95.7% and 90%, respectively. Thirteen patients showed side effects; four recurrences were recorded, of which 50% were out‐field relapses. The 5‐year Kaplan–Meier probability of local relapses, mastectomy‐free, and overall survival reached 97.5%, 100%, and 98%, respectively.Conclusions: This is the first 10‐year report about the effect of IORT on Mexican women with EBC in the early stages. Strict adherence to the selection criteria in this study resulted in low rates of side effects, mortality, and local recurrences, demonstrating that IORT is an effective treatment alternative for patients with EBC. Studies with a longer follow‐up period should be performed, as recurrences can occur in the long term.