Raffaella Nenna

Prof. Dr. Raffaella Nenna

Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
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Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 2017 in Gastroenterology
Verified
Journal Article
Closed access
PDF file
KWKatharina Julia Werkstetter
Katharina Julia Werkstetter
IKIlma Rita Korponay-Szabó
Ilma Rita Korponay-Szabó
APAlina Popp
Alina Popp
VVVincenzo Villanacci
Vincenzo Villanacci
MSMarianna Salemme
Marianna Salemme
ASAmir Taher Eftekhar Sadat
Amir Taher Eftekhar Sadat

18 July 2019 in European Respiratory Journal
Verified
Journal Article
Closed access
CWColin Wallis
Colin Wallis
EAEfthymia Alexopoulou
Efthymia Alexopoulou
JAJuan L. Antón-Pacheco
Juan L. Antón-Pacheco
JBJayesh M. Bhatt
Jayesh M. Bhatt
ABAndrew Bush
Andrew Bush
KPKostas Priftis
Kostas Priftis
Tracheomalacia and tracheobronchomalacia may be primary abnormalities of the large airways or associated with a wide variety of congenital and acquired conditions. The evidence on diagnosis, classification and management is scant. There is no universally accepted classification of severity. Clinical presentation includes early-onset stridor or fixed wheeze, recurrent infections, brassy cough and even near-death attacks, depending on the site and severity of the lesion. Diagnosis is usually made by flexible bronchoscopy in a free-breathing child but may also be shown by other dynamic imaging techniques such as low-contrast volume bronchography, computed tomography or magnetic resonance imaging. Lung function testing can provide supportive evidence but is not diagnostic. Management may be medical or surgical, depending on the nature and severity of the lesions, but the evidence base for any therapy is limited. While medical options that include bronchodilators, anti-muscarinic agents, mucolytics and antibiotics (as well as treatment of comorbidities and associated conditions) are used, there is currently little evidence for benefit. Chest physiotherapy is commonly prescribed, but the evidence base is poor. When symptoms are severe, surgical options include aortopexy or posterior tracheopexy, tracheal resection of short affected segments, internal stents and external airway splinting. If respiratory support is needed, continuous positive airway pressure is the most commonly used modality eitherviaa face mask or tracheostomy. Parents of children with tracheobronchomalacia report diagnostic delays and anxieties about how to manage their child's condition, and want more information. There is a need for more research to establish an evidence base for malacia. This European Respiratory Society statement provides a review of the current literature to inform future study.

2 April 2020 in European Respiratory Journal
Verified
Journal Article
Open access
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LCLuca Cristiani
Luca Cristiani
EMEnrica Mancino
Enrica Mancino
LMLuigi Matera
Luigi Matera
RNRaffaella Nenna
Raffaella Nenna
APAlessandra Pierangeli
Alessandra Pierangeli
Fabio MidullaFabio Midulla
Fabio Midulla
Epidemiological evidences show that SARS-CoV-2 infection in children is less frequent and severe than adults. Age-related ACE2 receptor expression, lymphocyte count and trained immunity might be the keystone to reveal children9s secret.

1 January 2009 in Human Immunology
Verified
Journal Article
Closed access
Francesca MegiorniFrancesca Megiorni
Francesca Megiorni
BMBarbara Mora
Barbara Mora
MBMargherita Bonamico
Margherita Bonamico
MBMaria Barbato
Maria Barbato
RNRaffaella Nenna
Raffaella Nenna
MMMaria Cristina Mazzilli
Maria Cristina Mazzilli

26 July 2021 in Pediatric Pulmonology
Verified
Journal Article
Open access
PDF file
GMGreta Di Mattia
Greta Di Mattia
RNRaffaella Nenna
Raffaella Nenna
EMEnrica Mancino
Enrica Mancino
VRValentina Rizzo
Valentina Rizzo
APAlessandra Pierangeli
Alessandra Pierangeli
Fabio MidullaFabio Midulla
Fabio Midulla
The diffusion of the SARS‐CoV‐2 virus and the implementation of restrictive measures led to a drastic reduction of respiratory syncytial virus (RSV) diffusion. Few RSV cases have been detected worldwide, even after the removal of the restrictions. We review the current literature and present possible explanations on why there has been a significant reduction of RSV detection during the COVID‐19 pandemic. We also hypothesize what may happen when RSV begins to circulate again. The increase of an immunologically naïve population, with infants born from mothers who have not reinforced their immunity to RSV, could lead to greater RSV epidemics in the coming seasons. It is crucial to prepare the scientific community and to keep RSV surveillance active to avoid dramatic consequences.

14 December 2017 in European Respiratory Journal
Verified
Journal Article
Closed access
PDF file
EEErnst Eber
Ernst Eber
JAJuan L. Antón-Pacheco
Juan L. Antón-Pacheco
JBJacques de Blic
Jacques de Blic
IDIolo Doull
Iolo Doull
AFAl Faro
Al Faro
Fabio MidullaFabio Midulla
Fabio Midulla
Paediatric airway endoscopy is accepted as a diagnostic and therapeutic procedure, with an expanding number of indications and applications in children. The aim of this European Respiratory Society task force was to produce a statement on interventional bronchoscopy in children, describing the evidence available at present and current clinical practice, and identifying areas deserving further investigation. The multidisciplinary task force panel performed a systematic review of the literature, focusing on whole lung lavage, transbronchial and endobronchial biopsy, transbronchial needle aspiration with endobronchial ultrasound, foreign body extraction, balloon dilation and occlusion, laser-assisted procedures, usage of airway stents, microdebriders, cryotherapy, endoscopic intubation, application of drugs and other liquids, and caregiver perspectives. There is a scarcity of published evidence in this field, and in many cases the task force had to resort to the collective clinical experience of the committee to develop this statement. The highlighted gaps in knowledge underline the need for further research and serve as a call to paediatric bronchoscopists to work together in multicentre collaborations, for the benefit of children with airway disorders.