Justin Davies

Mr. Justin Davies


Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 September 2019 in Gut
Verified
Journal Article
Open access
CLChristopher Andrew Lamb
Christopher Andrew Lamb
NKNicholas Alexander Kennedy
Nicholas Alexander Kennedy
TRTim Raine
Tim Raine
PHPhilip Anthony Hendy
Philip Anthony Hendy
PSPhilip J Smith
Philip J Smith
AHA Barney Hawthorne
A Barney Hawthorne
Ulcerative colitis and Crohn’s disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management relies on understanding and tailoring evidence-based interventions by clinicians in partnership with patients. This guideline for management of inflammatory bowel disease in adults over 16 years of age was developed by Stakeholders representing UK physicians (British Society of Gastroenterology), surgeons (Association of Coloproctology of Great Britain and Ireland), specialist nurses (Royal College of Nursing), paediatricians (British Society of Paediatric Gastroenterology, Hepatology and Nutrition), dietitians (British Dietetic Association), radiologists (British Society of Gastrointestinal and Abdominal Radiology), general practitioners (Primary Care Society for Gastroenterology) and patients (Crohn’s and Colitis UK). A systematic review of 88 247 publications and a Delphi consensus process involving 81 multidisciplinary clinicians and patients was undertaken to develop 168 evidence- and expert opinion-based recommendations for pharmacological, non-pharmacological and surgical interventions, as well as optimal service delivery in the management of both ulcerative colitis and Crohn’s disease. Comprehensive up-to-date guidance is provided regarding indications for, initiation and monitoring of immunosuppressive therapies, nutrition interventions, pre-, peri- and postoperative management, as well as structure and function of the multidisciplinary team and integration between primary and secondary care. Twenty research priorities to inform future clinical management are presented, alongside objective measurement of priority importance, determined by 2379 electronic survey responses from individuals living with ulcerative colitis and Crohn’s disease, including patients, their families and friends.

28 September 2010 in British Journal of Surgery
Verified
Journal Article
Open access
PDF file
ANA. Noorani
A. Noorani
NRN. Rabey
N. Rabey
SWS. R. Walsh
S. R. Walsh
JDJustin Davies
Justin Davies
Background: Surgical‐site infection increases morbidity, mortality and financial burden. The preferred topical antiseptic agent (chlorhexidine or povidone–iodine) for preoperative skin cleansing is unclear. Methods: A meta‐analysis of clinical trials was conducted to determine whether preoperative antisepsis with chlorhexidine or povidone–iodine reduced surgical‐site infection in clean‐contaminated surgery. Results: The systematic review identified six eligible studies, containing 5031 patients. Chlorhexidine reduced postoperative surgical‐site infection compared with povidone–iodine (pooled odds ratio 0·68, 95 per cent confidence interval 0·50 to 0·94; P = 0·019) . Conclusion: Chlorhexidine should be used preferentially for preoperative antisepsis in clean‐contaminated surgery. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

25 January 2018 in World Journal of Emergency Surgery
Verified
Journal Article
Open access
PDF file
Massimo SartelliMassimo Sartelli
Massimo Sartelli
YKYoram Kluger
Yoram Kluger
LALuca Ansaloni
Luca Ansaloni
Timothy Craig HardcastleTimothy Craig Hardcastle
Timothy Craig Hardcastle
JRJordi Rello
Jordi Rello
Fausto CatenaFausto Catena
Fausto Catena
The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.

3 December 2018 in Colorectal Disease
Verified
Journal Article
Open access
PDF file
SBS. R. Brown
S. R. Brown
NFN. S. Fearnhead
N. S. Fearnhead
OFO. D. Faiz
O. D. Faiz
JAJ. F. Abercrombie
J. F. Abercrombie
AAA. G. Acheson
A. G. Acheson
ACACPGBI IBD Surgery Consensus Collaboration
ACPGBI IBD Surgery Consensus Collaboration
Aim: There is a requirement of an expansive and up to date review of surgical management of inflammatory bowel disease (IBD) that can dovetail with the medical guidelines produced by the British Society of Gastroenterology.Methods: Surgeons who are members of theACPGBIwith a recognised interest inIBDwere invited to contribute various sections of the guidelines. They were directed to produce a procedure based document using literature searches that were systematic, comprehensible, transparent and reproducible. Levels of evidence were graded. An editorial board was convened to ensure consistency of style, presentation and quality. Each author was asked to provide a set of recommendations which were evidence based and unambiguous. These recommendations were submitted to the whole guideline group and scored. They were then refined and submitted to a second vote. Only those that achieved >80% consensus at level 5 (strongly agree) or level 4 (agree) after 2 votes were included in the guidelines.Results: All aspects of surgical care forIBDhave been included along with 157 recommendations for management.Conclusion: These guidelines provide an up to date and evidence based summary of the current surgical knowledge in the management ofIBDand will serve as a useful practical text for clinicians performing this type of surgery.

13 February 2025 in World Journal of Emergency Surgery
Verified
Journal Article
Open access
PDF file
Belinda De SimoneBelinda De Simone
Belinda De Simone
FAFikri M. Abu-Zidan
Fikri M. Abu-Zidan
LBLuigi Boni
Luigi Boni
ACAna Maria Gonzalez Castillo
Ana Maria Gonzalez Castillo
ECElisa Cassinotti
Elisa Cassinotti
FCFausto Catena
Fausto Catena
Decision-making in emergency settings is inherently complex, requiring surgeons to rapidly evaluate various clinical, diagnostic, and environmental factors. The primary objective is to assess a patient’s risk for adverse outcomes while balancing diagnoses, management strategies, and available resources. Recently, indocyanine green (ICG) fluorescence imaging has emerged as a valuable tool to enhance surgical vision, demonstrating proven benefits in elective surgeries. This consensus paper provides evidence-based and expert opinion-based recommendations for the standardized use of ICG fluorescence imaging in emergency settings. Using the PICO framework, the consensus coordinator identified key research areas, topics, and questions regarding the implementation of ICG fluorescence-guided surgery in emergencies. A systematic literature review was conducted, and evidence was evaluated using the GRADE criteria. A panel of expert surgeons reviewed and refined statements and recommendations through a Delphi consensus process, culminating in final approval. ICG fluorescence imaging, including angiography and cholangiography, improves intraoperative decision-making in emergency surgeries, potentially reducing procedure duration, complications, and hospital stays. Optimal use requires careful consideration of dosage and timing due to limited tissue penetration (5–10 mm) and variable performance in patients with significant inflammation, scarring, or obesity. ICG is contraindicated in patients with known allergies to iodine or iodine-based contrast agents. Successful implementation depends on appropriate training, availability of equipment, and careful patient selection. Advanced technologies and intraoperative navigation techniques, such as ICG fluorescence-guided surgery, should be prioritized in emergency surgery to improve outcomes. This technology exemplifies precision surgery by enhancing minimally invasive approaches and providing superior real-time evaluation of bowel viability and biliary structures—areas traditionally reliant on the surgeon’s visual assessment. Its adoption in emergency settings requires proper training, equipment availability, and standardized protocols. Further research is needed to evaluate cost-effectiveness and expand its applications in urgent surgical procedures.

1 May 2015 in Medicine
Verified
Journal Article
Open access
APAnna E. Page
Anna E. Page
SSShikha G. Sashittal
Shikha G. Sashittal
NCNikolaos A. Chatzizacharias
Nikolaos A. Chatzizacharias
JDJustin Davies
Justin Davies
Although laparoscopic surgery is readily used in the management of inflammatory bowel disease (IBD) in adults, its role in the surgical treatment of IBD in the pediatric population is not well established. The aim of this narrative review was to analyze the published evidence comparing laparoscopic and open resection in the management of children and adolescents with IBD. The Pubmed and Embase databases were searched using the terms "inflammatory bowel disease," "children," "adolescents," "laparoscopic," and "colectomy." The review identified 10 appropriate studies. Even though laparoscopic surgery generally resulted in longer operating times (between a mean of 40 and 140 min), benefits included reduced postoperative pain (mean duration of opiate use 3 vs 6 days) and reduced length of stay (median length of stay 5-8 vs 10.5-19 days) compared with open surgery. Postoperative complication rates were similar following both approaches. Due to the limited available data and the small sample size of the published series, definite recommendations are not able to be drawn. Nevertheless, current evidence indicates that laparoscopic colorectal resection is safe and feasible in the management of IBD in the paediatric population, with reductions in postoperative pain and length of hospital stay achievable.