The Wadi Samra–Wadi Kid district in southeastern Sinai, Egypt, has undergone extensive investigation involving remote sensing analysis, field geology studies, petrography, and geochemistry. The main aim of this study is the integration between remote sensing applications, fieldwork, and laboratory studies for accurate lithological mapping for future mineral exploration in the study region. The field relationships between these coincident rocks were studied in the study area. Landsat-8 (OLI) data that cover the investigated area were used in this paper. The different rock units in the study area were studied petrographically using a polarizing microscope, in addition to major and trace analysis using ICP-OES tools. The Operational Land Imager (OLI) images were used with several processing methods, such as false color composite (FCC), band ratio (BR), principal component analysis (PCA), and minimum noise fraction (MNF) techniques for detecting the different types of rock units in the Wadi Kid district. This district mainly consists of a volcano-sedimentary sequence as well as diorite, gabbro, granite, and albitite. Geochemically, the metasediments are classified as pelitic graywackes derived from sedimentary origin (i.e., shales). The Al₂O₃ and CaO contents are medium–high, while the Fe₂O₃ and TiO₂ contents are very low. Alkaline minerals are relatively low–medium in content. All of the metasediment samples are characterized by high MgO contents and low SiO₂, Fe₂O₃, and CaO contents. The granitic rocks appear to have alkaline and subalkaline affinity, while the subalkaline granites are high-K calc-alkaline to shoshonite series. The alkaline rocks are classified as albitite, while the calc-alkaline series samples vary from monzodiorites to granites. The outcomes of this study can be used for prospecting metallic and industrial mineral exploration in the Wadi Kid district.