Andrew J. Nasr

Mr. Andrew J. Nasr

orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 May 2024 in Muscles
Verified
Journal Article
Open access
PDF file
ANAndrew J. Nasr
Andrew J. Nasr
JHJoshua Harris
Joshua Harris
JWJijia Wang
Jijia Wang
MKMichael Khazzam
Michael Khazzam
NJNitin B Jain
Nitin B Jain
YLYen-Sheng Lin
Yen-Sheng Lin
Fatty infiltration of the rotator cuff muscles is very common following rotator cuff tears and is one of the most important factors in determining treatment. Current clinical practice relies on subjective evaluation of fatty infiltration through categorical scoring based on the Goutallier classification system. The Dixon magnetic resonance imaging (MRI) sequence provides flexibility in selecting echo times for water–fat separation. The Dixon method, therefore, has the potential to provide robust and high-quality fat quantification that allows for more accurate calculation of fat fraction (%Fat) of the rotator cuff muscles than the Goutallier classification system. However, significant variance exists in sequencing and post-processing methodology within the recent application of Dixon sequences to quantify rotator cuff fatty infiltration. In this paper, we conducted a systematic review to synthesize the relevant literature utilizing Dixon sequencing for the quantification of rotator cuff fatty infiltration. The literature search was extracted from 1094 articles, with 12 studies included in the final review. Regardless of the varying sequencing pattern and post-processing techniques among studies, the findings suggest the Dixon method is reliable for quantitatively calculating the fat fraction of the rotator cuff muscles, even at very low levels of fatty infiltration. In addition, a quantitative difference in fat fraction was observed between participants with different degrees of tear vs. those without any shoulder pathologies. Multi-point Dixon imaging has the potential to be utilized clinically to objectively quantify fatty infiltration and may lead to improved clinical decision making for patients with rotator cuff tears.

9 June 2023 in Diagnostics
Verified
Journal Article
Open access
PDF file
ANAndrew J. Nasr
Andrew J. Nasr
CPChris J. Pierson
Chris J. Pierson
YTYi-Ting Tzen
Yi-Ting Tzen
MKMichael Khazzam
Michael Khazzam
NJNitin B Jain
Nitin B Jain
YLYen-Sheng Lin
Yen-Sheng Lin
Rotator cuff myosteatosis following cuff tears is very common and one of the most important prognostic factors in clinical management. Quantitative ultrasound-based imaging techniques (QUBIT) are frequently used along with magnetic resonance imaging (MRI) to evaluate rotator cuff fatty degeneration. However, the examination of rotator cuff tissue integrity by QUBIT is lacking a standardized imaging protocol and procedural methodologies. In this scoping review, we synthesized the current state of QUBIT against the reference imaging modalities in patients with rotator cuff tears. The literature search was extracted from 963 studies, with 22 studies included in the final review in accordance with the preferred reporting items for systematic reviews and meta-analyses extensions for scoping reviews. The selected studies included human participants and focused on measuring at least one prognostic or diagnostic factor using ultrasonography-based imaging with reference to MRI. The findings suggest both conventional B-mode ultrasound and shear wave elastography imaging were comparable to MRI-based imaging techniques for the evaluation of fatty infiltration and rotator cuff tear characterization. This review establishes guidelines for reporting shoulder-specific QUBIT aimed at developing a standardized imaging protocol. The objective was to enhance the diagnostic and prognostic capabilities of QUBIT in the clinical setting.

6 September 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
KPKevin Prabhu
Kevin Prabhu
ANAndrew J. Nasr
Andrew J. Nasr
DKDonald Kasitinon
Donald Kasitinon
ACAlison Cabrera
Alison Cabrera
YLYen-Sheng Lin
Yen-Sheng Lin
Impaired shoulder function hinders the ability of wheelchair users to maintain independence. The current state of the literature delineates the risks and benefits of surgical techniques for the management of shoulder pathologies. To the best of our knowledge, there is no study that has investigated complications following total shoulder arthroplasty (TSA) in wheelchair users. Utilizing the PearlDiver Mariner national administrative database, 72,108 patients were identified who underwent TSA with a concurrent diagnosis of a rotator cuff tear. Two matched cohorts, one of wheelchair users and one of non-wheelchair users, were created. Due to limitations within PearlDiver, one-year outcomes, including comorbidity and complication rates and readmission statistics, were compared between the two cohorts. Each matched cohort of 869 patients underwent TSA with a concurrent diagnosis of a rotator cuff tear. The rate of readmission in wheelchair users was greater than in non-wheelchair users (24.05% vs. 9.55%, OR: 3.00, CI: 2.279, 3.946). Patients in the wheelchair cohort exhibited higher rates of complications and comorbidities (p < 0.001). Among the most likely to be readmitted after TSA were patients with osteoarthritis, pulmonary heart disease, rheumatoid arthritis, and hypertension (p < 0.05). Significant differences in surgical outcomes existed between wheelchair and non-wheelchair users in terms of preoperative comorbidities, postoperative complications, and readmission rates.

17 January 2024 in Seminars in Arthroplasty: JSES
Verified
Journal Article
Closed access
ANAndrew J. Nasr
Andrew J. Nasr
AKAlexander Kowalske
Alexander Kowalske
JWJijia Wang
Jijia Wang
NJNitin B Jain
Nitin B Jain
MKMichael Khazzam
Michael Khazzam

1 April 2019 in Journal of Bodywork and Movement Therapies
Verified
Journal Article
Closed access
ANAndrew J. Nasr
Andrew J. Nasr
JZJason Zafereo
Jason Zafereo

1 May 2025 in Digital Health
Verified
Journal Article
Open access
ANAndrew J. Nasr
Andrew J. Nasr
KBKhosrow Behbehani
Khosrow Behbehani
JWJijia Wang
Jijia Wang
CPChristopher Pierson
Christopher Pierson
RJRobin B. Jarrett
Robin B. Jarrett
JZJason Zafereo
Jason Zafereo
Background: Reduced heart rate variability (HRV) has been associated with impaired autonomic nervous system (ANS) adaptation, suggesting that HRV could serve as a biomarker for identifying ANS imbalances that may adversely affect an individual's overall health. Many wearable devices used outside medical settings provide measures of HRV, but clinimetric data on their reliability and agreement remain limited. The primary aim of this study was to assess the ability of the Fitbit Versa 4, a consumer-based wearable, to measure nocturnal HRV compared to a reference standard HRV measure obtained from an ambulatory ECG device, the Firstbeat Bodyguard 3. Methods: Eight participants simultaneously wore the Fitbit Versa 4 and Firstbeat Bodyguard 3 beginning at least one hour before sleep, throughout their sleep period, and for at least one hour after waking, over a minimum of three nights. HRV was quantified using the root mean square of successive differences (RMSSD). A t-test assessed differences in median HRV between devices, while a Linear Mixed Model and Bland-Altman analysis evaluated relative difference and agreement, respectively. Results: The median RMSSD from Fitbit (21.660 ms [15.927, 22.821]) was not significantly different ( p = 0.3858) from the median RMSSD from Firstbeat (20.558 ms [13.648, 21.828]. Linear Mixed Model results indicated that, on average, Firstbeat measurements were approximately 92.3% of those obtained from Fitbit. Conclusions: Strong correlation and acceptable agreement between Fitbit Versa 4 HRV measurements and reference standard HRV measurements derived from ECG provide preliminary support for using Fitbit Versa 4 to measure nocturnal HRV outside laboratory settings.