The highly sensitive detection and imaging of biomarkers are critical for early diagnosis, treatment, and prognosis monitoring. The unique size and structure of fluorescent nanomaterials provide key benefits such as excellent photostability, high fluorescence quantum yield, and tunable excitation and emission wavelengths. These properties have led to the widespread application of nanomaterials in fluorescent biomarkers detection and imaging. In this review, we began by introducing the composition of fluorescent probes and discussing the underlying sensing mechanisms. We then summarized recent advances in the use of fluorescent nanomaterials such as quantum dots (QDs), metal nanoclusters (MNCs), carbon dots (CDs), and metal-organic frameworks (MOFs) for biomarker detection and imaging. Additionally, we highlighted the applications of fluorescent nanomaterials in the detection and imaging of small molecules, biomacromolecules, and various biomarkers, including metal ions, bacteria, and circulating tumor cells (CTCs). The challenges and future prospects of fluorescent nanomaterials in biomarker detection and imaging were also discussed. We anticipate that fluorescent nanomaterials will have profound implications for clinical biomarker detection and imaging, with considerable application in both academic research and industrial applications.

In schizophrenia, executive dysfunction is the most critical cognitive impairment, and is associated with abnormal neural activities, especially in the frontal lobes. Complexity estimation using electroencephalogram (EEG) recording based on nonlinear dynamics and task performance tests have been widely used to estimate executive dysfunction in schizophrenia. The present study estimated the cool executive function based on fractal dimension (FD) values of EEG data recorded from first-episode schizophrenia patients and healthy controls during the performance of three cool executive function tasks, namely, the Trail Making Test-A (TMT-A), Trail Making Test-B (TMT-B), and Tower of Hanoi tasks. The results show that the complexity of the frontal EEG signals that were measured using FD was different in first-episode schizophrenia patients during the manipulation of executive function. However, no differences between patients and controls were found in the FD values of the EEG data that was recorded during the performance of the Tower of Hanoi task. These results suggest that cool executive function exhibits little impairment in first-episode schizophrenia patients.

Our study aims to examine stress–strain data of the four major knee ligaments—the anterior cruciate ligament (ACL), the posterior cruciate ligament (PCL), the medial collateral ligament (MCL), and the lateral collateral ligament (LCL)—under transient impacts in various knee joint regions and directions within the static standing position of the human body. Subsequently, we will analyze the varying biomechanical properties of knee ligaments under distinct loading conditions. A 3D simulation model of the human knee joint including bone, meniscus, articular cartilage, ligaments, and other tissues, was reconstructed from MRI images. A vertical load of 300 N was applied to the femur model’s top surface to mimic the static standing position, and a 134 N load was applied to the impacted area of the knee joint. Nine scenarios were created to examine the effects of anterior, posterior, and lateral external forces on the upper, middle, and lower regions of the knee joint. The PCL exhibited the highest stress levels among the four ligaments when anterior loads were applied to the upper, middle, and lower parts of the knee, with maximum stresses at the PCL-fibula junction measuring 59.895 MPa, 27.481 MPa, and 28.607 MPa, respectively. Highest stresses on the PCL were observed under posterior loads on the upper, middle, and lower knee areas, with peak stresses of 57.421 MPa, 38.147 MPa, and 26.904 MPa, focusing notably on the PCL-tibia junction. When a lateral load was placed on the upper knee joint, the ACL showed the highest stress 32.102 MPa. Likewise, in a lateral impact on the middle knee joint, the ACL also had the highest stress of 29.544 MPa, with peak force at the ACL-tibia junction each time. In a lateral impact on the lower knee area, the LCL had the highest stress of 22.279 MPa, with the highest force at the LCL-fibula junction. Furthermore, the maximum stress data table indicates that stresses in the ligaments are typically higher when the upper portion of the knee is affected compared to when the middle and lower parts are impacted. This study recommends people avoid impacting the upper knee and use the middle and lower parts of the knee effectively against external forces to minimize ligament damage and safeguard the knee.

Special equipment drivers often suffered from vibration which threatened their physical and mental health. In order to study the riding comfort of a special equipment cab, a hammering experiment has been carried out on it by acceleration sensors. According to the test results, the natural frequency has been calculated which was compared with the result analysis by the finite element method. Next, the equipment operating condition test on a flat road was done. The vibration characteristics of the whole vehicle were obtained later. The results show that the cab vibration and the finite element results agree well, but the natural frequency of the cab is close to the vibration frequency of the human body. And this is not conducive to long-term operation of the drivers. In order to improve the human operational comfort, it is necessary to reduce its natural frequency during the cab structure design process. The research in this paper can provide help for the similar human-machine operation comfort study and product design.

By far there is lack of research on different working conditions between rigid and flexible dynamics of truck mounted concrete pump booms. First a 3D model has been established by using virtual prototyping technology of a 37 m long boom in Pro/Engineering software. Then the rigid body simulation model has been built. Next modal superimposition method is adopted to change the 4 rigid body booms into flexible ones. Kinematics law and dynamic characteristics of 4 common working conditions had been studied then. Next tip displacement and the first boom hydraulic cylinder force of the 4 working conditions between rigid and flexible models have been researched. Furthermore the first natural frequencies of the structure have been calculated. The results show that the frequency of the horizontal condition has the lowest of all and the roof condition has the largest of all. Besides the cylinder forces of the flexible model are larger than the corresponding rigid ones because of the flexible boom vibration. Finally an experiment has been done on a boom test rig which proved that the established simulation model is reasonable and the frequency results are correct. All of these provide design reference to mechanical manipulator as well as reducing product development cost of such mechanism.

The trend item of a long-term vibration signal is difficult to remove. This paper proposes a piecewise integration method to remove trend items. Examples of direct integration without trend item removal, global integration after piecewise polynomial fitting with trend item removal, and direct integration after piecewise polynomial fitting with trend item removal were simulated. The results showed that direct integration of the fitted piecewise polynomial provided greater acceleration and displacement precision than the other two integration methods. A vibration test was then performed on a special equipment cab. The results indicated that direct integration by piecewise polynomial fitting with trend item removal was highly consistent with the measured signal data. However, the direct integration method without trend item removal resulted in signal distortion. The proposed method can help with frequency domain analysis of vibration signals and modal parameter identification for such equipment.