Climate change–driven increases in drought and rainfall variability present new challenges for grape production, even in regions with historically high precipitation. Rootstock selection and irrigation management are important tools for optimizing vine performance and fruit and wine composition, yet their combined effects remain poorly understood in hybrid grape cultivars grown in humid regions. We evaluated own-rooted Chambourcin and vines grafted to 1103 Paulsen (1103P), 3309 Couderc (3309C), and SO4 under three irrigation regimes (none, 50% ET replacement, and full irrigation) over three growing seasons in Missouri, USA. Across 105 trait-by-year combinations, including vine physiology, yield components, berry chemistry, and berry and wine volatiles, we partitioned variance explained by irrigation, rootstock, their interaction, and vineyard block. Irrigation exerted year-dependent effects on vine water status, gas exchange, organic acids, and selected volatiles, with the strongest physiological responses in 2014, when precipitation was lowest and water-balance deficit was greatest. However, irrigation effects were not limited to this dry year, as selected berry chemistry, vine growth, and wine volatile traits also differed among irrigation treatments in years with less pronounced water stress. Rootstock consistently influenced vine size and vine balance, with 1103P and 3309C increasing pruning weight and generally lowering Ravaz indices, while yield responses were more vintage dependent. Berry volatile composition was only modestly affected, whereas wine volatile profiles were more strongly shaped by rootstock, particularly for norisoprenoids, esters, and terpenes. Grafted-versus-own-rooted contrasts identified 24 affected variables, but these responses reflect grafting to the evaluated rootstocks rather than graft-union effects alone. Overall, irrigation and rootstock exerted partially distinct but complementary influences, highlighting the importance of integrated water and rootstock management for optimizing hybrid grapevine performance and wine style in humid environments.