With rapid advances in quantum hardware, a central question is whether quantum devices with or without full error correction can outperform classical computers on practically relevant problems. Variational quantum algorithms (VQAs) have gained significant attention as promising candidates in this pursuit, particularly for combinatorial optimization problems. While reports of their challenges and limitations continue to accumulate, many studies remain optimistic based on small-scale, idealized testing setups, leaving doubt about the scalability of VQAs for large-scale problems. We systematically investigate this scaling behavior by analyzing how classical optimizers minimize variational quantum loss functions for random Quadratic Unconstrained Binary Optimization instances in the presence of uncertainty, modeled as effective Gaussian noise. We find that the critical noise threshold for successful optimization decreases rapidly as system size grows. This decline exceeds what can be explained solely by shrinking loss variance, confirming deeper, fundamental limitations in the loss landscapes of VQAs beyond barren plateaus. Translating these thresholds into required measurement shots reveals that achieving sufficient precision in the evaluated loss values quickly becomes impractical, even for moderatelysized problems. Our findings demonstrate serious scalability challenges for VQAs in optimization stemming from mere uncertainty, indicating potential barriers to achieving practical quantum advantage with current hybrid approaches.

This paper presents a solution for efficiently and accurately solving separable least squares problems with multiple datasets. These problems involve determining linear parameters that are specific to each dataset while ensuring that the nonlinear parameters remain consistent across all datasets. A well-established approach for solving such problems is the variable projection algorithm introduced by Golub and LeVeque, which effectively reduces a separable problem to its nonlinear component. However, this algorithm assumes that the datasets have equal sizes and identical auxiliary model parameters. This article is motivated by a real-world remote sensing application where these assumptions do not apply. Consequently, we propose a generalized algorithm that extends the original theory to overcome these limitations. The new algorithm has been implemented and tested using both synthetic and real satellite data for atmospheric carbon dioxide retrievals. It has also been compared to conventional state-of-the-art solvers, and its advantages are thoroughly discussed. The experimental results demonstrate that the proposed algorithm significantly outperforms all other methods in terms of computation time, while maintaining comparable accuracy and stability. Hence, this novel method can have a positive impact on future applications in remote sensing and could be valuable for other scientific fitting problems with similar properties.

In the era of expanding manned space missions, understanding the biomechanical impacts of zero gravity on human movement is pivotal. This study introduces a novel and cost-effective framework that demonstrates the application of Microsoft’s Azure Kinect body tracking technology as a motion input generator for subsequent OpenSim simulations in weightlessness. Testing rotations, locomotion, coordination, and martial arts movements, we validate the results’ realism under the constraints of angular and linear momentum conservation. While complex, full-body coordination tasks face limitations in a zero gravity environment, our findings suggest possible approaches to device-free exercise routines for astronauts and reveal insights into the feasibility of hand-to-hand combat in space. However, some challenges remain in distinguishing zero gravity effects in the simulations from discrepancies in the captured motion input or forward dynamics calculations, making a comprehensive validation difficult. The paper concludes by highlighting the framework’s practical potential for the future of space mission planning and related research endeavors, while also providing recommendations for further refinement.