Background: A stoma poses numerous physical, social, and psychological challenges and interferes with some religious practices, thus potentially negatively affecting the quality of life. In the contemporary era of stoma care, the study sought to assess this impact in a population with distinctive sociocultural characteristics. Methods: A modified City of Hope Quality of Life ostomy questionnaire was used to survey patients with intestinal stomas. The scoring was dichotomous on a 0 to 10 scale, where 0–3 indicated severe impact, 4–6 moderate, and 7–10 minimum. Statistical analysis involved Student’s t-test, one-way ANOVA, Spearman’s correlation, and multivariate linear regression. Results: There were 108 patients, with 59 males and 49 females. The mean age was 40.8 years. The overall quality of life score was 6, for the social domain 7, the physical domain 6, the psychological domain 5, and the spiritual domain 6. The stoma’s impact on the quality of life was severe in 2%, moderate in 61%, and minimal in 37% of patients. Young patients, women, and those with benign diseases or without a job had low scores. Furthermore, 90% of patients had difficulty performing religious activities. For the regression analysis, life quality predictors were dietary, religious, pouch and stoma site issues, leak, odor, diarrhea or constipation, depression, anxiety, and future and disease concerns. Conclusions: Despite advances in stoma care, stoma patients had multiple impediments to their life quality. These were mainly psychological, but the physical and religious ones were also significant. A holistic approach to managing stoma patients is thus needed to help them have fulfilling lives.