Introduction: Elderly people may suffer from the multiple health disorders due to the vulnerability for many physical and mental disturbances. Quality of life in elderly population can be affected by many environmental factors. The aim of this study was aimed to examine the quality of life in elderly people in Tabriz, Iran in 2012. Methods: This cross-sectional study was carried out on 184 elderly people (male=97; female=87) with age ≥ 60 years. The participants surveyed in this study were elderly people who were living in the community and come voluntarily to the daily care centers. Validated Persian self-reported version of World Health Organization Quality of Life-BRIEF (WHOQOL-BRIEF) questionnaire including 26 broad and comprehensive questions were used to determine the quality of life in elderly people. Independent t-test and Pearson correlation were used to compare differences and correlation between the total score of quality of life and influential factors. Results: Total score the quality of life in both genders was 90.75 (13.37) (range between 26-130). Male elderly had slightly high score in the quality of life; however, these differences were not significant. A significant difference was observed between having cardiovascular diseases, respiratory and gastrointestinal diseases, hearing and visual impairments with total score in the quality of life. Also, there was no significant difference between gender and age variables with total score in the quality of life. Conclusion: Policies and programs should be considered for improving the quality of life. Future studies are needed for assessing other influential factors on the quality of life in elderly population.
29 August 2018 in Advanced Pharmaceutical Bulletin
Purpose: Obesity as a serious public health problem worldwide, results in the incidence of many chronic diseases. Obesity has been recognized as a chronic low-grade inflammation disorder. Altered endocannabinoid system tone is also involved in the pathogenesis of obesity. The present study aimed to investigate the effects of oleoylethanolamide supplementation on inflammatory biomarkers and oxidative stress in obese people. Methods: This randomized, double-blind, placebo-controlled clinical trial was carried out on 60 healthy obese people in 2016 in Tabriz, Iran. Eligible subjects were randomly divided into intervention (received daily, two 125 mg OEA capsules) and control groups (the same amounts of starch) and treated for 8 weeks. Blood samples (5 ml) were taken in fasting state at the baseline and at the end of the study. The concentrations of MDA and TAS were measured using a spectrophotometer. A high sensitive-C reactive protein level was measured by Immunoturbidimetry assay using the commercial kit. IL-6 and TNF-α levels were assayed by the ELISA method. The differences between groups were assessed by ANCOVA and statistical significance was determined at p<0.05. Results: Analysis was done on 56 participants who continued intervention until the end of the study. A significant decrease in the IL-6 and TNF-α serum concentrations was observed in the intervention group (p0.05). Conclusion: The use of OEA as a complementary pharmacotherapy agent could be effective in improving inflammation and oxidative stress in obese people. Future studies are needed to confirm the obtained results.