Md Serajul Haque Faizi

Dr. Md Serajul Haque Faizi

orcid

Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2017 in Bioorganic & Medicinal Chemistry
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Journal Article
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AHAshanul Haque
Ashanul Haque
MFMd Serajul Haque Faizi
Md Serajul Haque Faizi
JRJahangir Ahmad Rather
Jahangir Ahmad Rather
Muhammad S. KhanMuhammad S. Khan
Muhammad S. Khan

Verified
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Ching-Yi ChengChing-Yi Cheng
Ching-Yi Cheng
AHAshanul Haque
Ashanul Haque
MHMing-Fa Hsieh
Ming-Fa Hsieh
SHSyed Imran Hassan
Syed Imran Hassan
MFMd Serajul Haque Faizi
Md Serajul Haque Faizi
Muhammad S. KhanMuhammad S. Khan
Muhammad S. Khan
Inflammation is a hallmark of many metabolic diseases. We previously showed that ferrocene-appended 1H-1,2,3-triazole hybrids inhibit nitric oxide (NO) production in in vitro models of lipopolysaccharide-induced inflammation in the BV-2 cell. In the present study, we explored the viability, anti-inflammatory, and antioxidant potential of ferrocene-1H-1,2,3-triazole hybrids using biochemical assays in rat mesangial cells (RMCs). We found that, among all the ferrocene-1H-1,2,3-triazole hybrids, X2–X4 exhibited an antioxidant effect on mitochondrial free radicals. Among all the studied compounds, X4 demonstrated the best anti-inflammatory effect on RMCs. These results were supplemented by in silico studies including molecular docking with human cytosolic phospholipase A2 (cPLA2) and cyclooxygenase 2 (COX-2) enzymes as well as absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling. Besides, two new crystal structures of the compounds have also been reported. In addition, combining the results from the inducible nitric oxide synthase (iNOS), cPLA2, COX-2, and matrix metalloproteinase-9 (MMP-9) enzymatic activity analysis and NO production also confirmed this argument. Overall, the results of this study will be a valuable addition to the growing body of work on biological activities of triazole-based compounds.

6 December 2023 in Journal of Molecular Structure
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Journal Article
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AJAsif Jamal
Asif Jamal
MFMd Serajul Haque Faizi
Md Serajul Haque Faizi
NDNecmi DEGE
Necmi DEGE

19 February 2015 in RSC Advances
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NKNasim Khan
Nasim Khan
SKShaik Karamthulla
Shaik Karamthulla
LCLokman H. Choudhury
Lokman H. Choudhury
MFMd Serajul Haque Faizi
Md Serajul Haque Faizi
A simple and benign one-pot protocol for the synthesis of 2-amino selenopyridine derivatives 4 has been developed using ultrasound assisted multicomponent reactions of aldehydes, malononitrile and benzeneselenol in polyethylene glycol (PEG-400). Under similar reaction conditions, sterically hindered o,o′-disubstituted aromatic aldehydes provide the corresponding functionalized seleno dihydropyridines 5. In this process in total four new bonds (two C–C, one C–N and one C–Se) forms in one pot.

6 December 2017 in Journal of Molecular Structure
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Journal Article
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MFMd Serajul Haque Faizi
Md Serajul Haque Faizi
MAMohammad Jane Alam
Mohammad Jane Alam
AHAshanul Haque
Ashanul Haque
SAShabbir Ahmad
Shabbir Ahmad
MSM. Shahid
M. Shahid
Musheer AhmadMusheer Ahmad
Musheer Ahmad

21 June 2019 in Acta Crystallographica Section E Crystallographic Communications
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SDSaid Daoui
Said Daoui
MFMd Serajul Haque Faizi
Md Serajul Haque Faizi
EFEL KALAI fouad
EL KALAI fouad
RSRafik Saddik
Rafik Saddik
NDNecmi DEGE
Necmi DEGE
NBNoureddine Benchat
Noureddine Benchat
The title pyridazin-3(2H)-one derivative, C25H19FN2O2, crystallizes with two independent molecules (A and B) in the asymmetric unit. In molecule A, the 4-fluorophenyl ring, the benzyl ring and the phenyl ring are inclined to the central pyridazine ring by 86.54 (11), 3.70 (9) and 84.857 (13)°, respectively. In molecule B, the corresponding dihedral angles are 86.80 (9), 10.47 (8) and 82.01 (10)°, respectively. In the crystal, the A molecules are linked by pairs of C—H...F hydrogen bonds, forming inversion dimers with an R 2 2(28) ring motif. The dimers are linked by C—H...O hydrogen bonds and a C—H...π interaction, forming columns stacking along the a-axis direction. The B molecules are linked to each other in a similar manner and form columns separating the columns of A molecules.