N-doped carbon quantum dots (N-CQDs) derived from the Rumex crispus L. plant were incorporated into TiO₂ via a facile hydrothermal method. As-prepared materials were characterized and used in the photocatalytic tetracycline (TC) degradation under UVA light irradiation by examining several operational parameters involving the N-CQDs amount, initial TC concentration, pH, and photocatalytic reaction time. XRD analysis revealed the conversion of the rutile phase to the anatase phase after the incorporation of N-CQDs into the TiO₂ structure. The results revealed that the N-CQDs/TiO₂ photocatalysts demonstrated the highest efficiency in TC degradation compared to other processes of adsorption, photolysis (UVA), and photocatalysis with TiO₂ (TiO₂/UVA). Under optimized conditions, 10 mg/L TC at pH 5.15 with 0.2 g/L N-CQDs/TiO₂ catalyst showed 97.7% photocatalytic degradation for 120 min under UVA irradiation. The formation of an S-scheme heterojunction between N-CQDs and TiO₂ provided enhanced charge separation and strong redox capability, causing significant improvement in the photocatalytic performance of N-CQDs/TiO₂. Trapping experiments showed that O₂^•- and h⁺ are the predominant reactive species for the TC elimination in an aqueous solution.