Maziar Mohaddes

Dr. Maziar Mohaddes


Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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6 February 2019 in BMC Musculoskeletal Disorders
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Journal Article
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RZRoland Zugner
Roland Zugner
RTRoy Tranberg
Roy Tranberg
JTJohn Timperley
John Timperley
DHDiana Hodgins
Diana Hodgins
MMMaziar Mohaddes
Maziar Mohaddes
JKJohan Kärrholm
Johan Kärrholm
Patient reported outcome measurement (PROMs) will not capture in detail the functional joint motion before and after total hip arthroplasty (THA). Therefore, methods more specifically aimed to analyse joint movements may be of interest. An analysis method that addresses these issues should be readily accessible and easy to use especially if applied to large groups of patients, who you want to study both before and after a surgical intervention such as THA. Our aim was to evaluate the accuracy of inertial measurement units (IMU) by comparison with an optical tracking system (OTS) to record pelvic tilt, hip and knee flexion in patients who had undergone THA. 49 subjects, 25 males 24 females, mean age of 73 years (range 51–80) with THA participated. All patients were measured with a portable IMU system, with sensors attached lateral to the pelvis, the thigh and the lower leg. For validation, a 12-camera motion capture system was used to determine the positions of 15 skin markers (Oqus 4, Qualisys AB, Sweden). Comparison of sagittal pelvic rotations, and hip and knee flexion-extension motions measured with the two systems was performed. The mean values of the IMU’s on the left and right sides were compared with OTS data. The comparison between the two gait analysis methods showed no significant difference for mean pelvic tilt range (4.9–5.4 degrees) or mean knee flexion range (54.4–55.1 degrees) on either side (p > 0.7). The IMU system did however record slightly less hip flexion on both sides (36.7–37.7 degrees for the OTS compared to 34.0–34.4 degrees for the IMU, p < 0.001). We found that inertial measurement units can produce valid kinematic data of pelvis- and knee flexion-extension range. Slightly less hip flexion was however recorded with the inertial measurement units which may be due to the difference in the modelling of the pelvis, soft tissue artefacts, and malalignment between the two methods or misplacement of the inertial measurement units. The study has ethical approval from the ethical committee “Regionala etikprövningsnämnden i Göteborg” (Dnr: 611–15, 2015-08-27) and all study participants have submitted written approval for participation in the study.

11 January 2017 in International Orthopaedics
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Journal Article
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MMMaziar Mohaddes
Maziar Mohaddes
PCPeter Cnudde
Peter Cnudde
MPMartin Paulsson
Martin Paulsson
AWAlexander Wall
Alexander Wall
JKJohan Kärrholm
Johan Kärrholm
Purpose Dislocation after total hip arthroplasty (THA) is a common reason for revision. The last decade fostered a significant increase in the use of dual-mobility cups (DMCs). Here we report our study on the short-term survival rate of a cemented DMC reported to the Swedish Hip Arthroplasty Register (SHAR) compared with other cemented designs used in first-time revision due to dislocation. Methods During 2005–2015, 984 first-time revisions for dislocation were reported to SHAR. In 436 of these cases a cemented dual articular cup was used. During the same time period, 355 revisions performed with a standard cemented cup (femoral head size 28–36 mm) were reported to the SHAR. Patients receiving a DMC were slightly older (75 years, p = 0.005). Re-revision for all reasons was used as primary endpoint. We also anlaysed risk for re-revision of the acetabular component and re-revision due to dislocation. Kaplan–Meier implant survival and a Cox regression analyses adjusted for age and gender were performed. Results Implant survival at 4 years for all reasons (91% ± 3.7% vs 86% ± 4.1%, p = 0.02), and especially for re-operation because of dislocation, favours the DMC group (96% ± 3.0% vs 92% ± 3.3%, p = 0.001). Discussion Our findings indicate that use of a cemented DMC reduces the short- to mid-term risk of a second revision in first-time revisions compared with classic cup designs. Longer follow-up is needed to establish any long-term clinical advantages when DMCs are used in revisions performed due to dislocation.

27 April 2015 in HIP International
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Journal Article
Closed access
TKTina Klerken
Tina Klerken
MMMaziar Mohaddes
Maziar Mohaddes
SNSzilard Nemes
Szilard Nemes
JKJohan Kärrholm
Johan Kärrholm
Introduction: Radiostereometric analysis (RSA) is an accurate and precise measurement tool of migration and rotation of implants. We investigated if early migration measured with RSA can be used to predict the risk of later aseptic loosening in acetabular revision surgery. Patients and methods: A total of 312 patients who underwent acetabular revision surgery were followed by RSA measurements for 2 to 20 years. The endpoint was either re-revision due to aseptic loosening or loosening on last available radiographic examination. Cox regression model was used to evaluate the predictive value of early migration. Results: A total of 16 acetabular cups were re-revised due to aseptic loosening and 7 unrevised cups were radiographically loose. Every mm of proximal migration 2 years postoperatively increased the risk of aseptic loosening by 37% (hazard ratio (HR) 1.37, 95% confidence interval (CI) 1.18-1.58). Adjusting for differences in base line demographics, bone defects and surgical techniques in a Cox regression model, risk of aseptic loosening with every mm of proximal migration was even higher (HR 1.94, 95% CI 1.34-2.82, p<0.001). Conclusions: We found a strong relationship between early migration measured by RSA and risk of late aseptic loosening in acetabular revision surgery. Monitoring proximal migration with RSA should be considered as an essential step in quality assessment when new implants and novel techniques are introduced in acetabular revision surgery.

10 April 2019 in Journal of Clinical Medicine
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KSKarin Svensson
Karin Svensson
MPMartin Paulsson
Martin Paulsson
JKJohan Kärrholm
Johan Kärrholm
MMMaziar Mohaddes
Maziar Mohaddes
Late chronic infection is a devastating complication after total hip arthroplasty (THA) and is often treated with surgery. The one-stage surgical procedure is believed to be the more advantageous from a patient and cost perspective, but there is no consensus on whether the one- or two-stage procedure is the better option. We analysed the risk for re-revision in infected primary THAs repaired with either the one- or two-stage method. Data was obtained from the Swedish Hip Arthroplasty Register and the study groups were patients who had undergone a one-stage (n = 404) or two-stage (n = 1250) revision due to infection. Risk of re-revision was analysed using Kaplan–Meier analysis with log-rank test and Cox regression analysis. The cumulative survival rate was similar in the two groups at 15 years after surgery (p = 0.1). Adjusting for covariates, the risk for re-revision due to all causes did not differ between patients who were operated on with the one- or two-stage procedure (Hazard Ratio (HR) = 0.9, 95% Confidence Interval (C.I.) = 0.7–1.2, p = 0.5). The risk for re-revision due to infection (HR = 0.7m, 95% C.I. = 0.4–1.1, p = 0.2) and aseptic loosening (HR = 1.2, 95% C.I. = 0.8–1.8, p = 0.5) was similar. This study could not determine whether the one-stage method was inferior in cases when the performing surgeons chose to use the one-stage method.

2 April 2019 in Acta Orthopaedica
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Journal Article
Open access
MMMaziar Mohaddes
Maziar Mohaddes
ENEmma Nauclér
Emma Nauclér
JKJohan Kärrholm
Johan Kärrholm
HMHenrik Malchau
Henrik Malchau
DODaniel Odin
Daniel Odin
MPMartin Paulsson
Martin Paulsson
Background and purpose — The outcome of total hip arthroplasty (THA) in younger patients is suggested to be inferior compared with the general THA population. There is a lack of studies with long-term follow up for very young patients. We report on implant survival and patient-reported outcome in patients aged 30 years or younger. Patients and methods — Data on THAs performed in Sweden between the years 2000 and 2016 were included. There were 504 patients 30 years or younger with complete demographic and surgical data (study group). A matched comparison group older than 30 years was identified. Implant survival was analyzed using the Kaplan–Meier method. Patient-reported outcome was analyzed in a subgroup of patients. Results — The 10-year and 15-year implant survivorship for the study group was 90% and 78%, respectively. The corresponding figures for the patients older than 30 years were 94% and 89%. The median preoperative EQ-5D index was lower in the study group; the improvement in EQ-5D index was similar between the study and the comparison groups. The preoperative EQ-VAS was lower and the improvement in EQ-VAS at 1 year was larger in the study group. Interpretation — The promising 10-year implant survival and 1-year improvement in patient-reported outcome suggests that THA is a feasible option in the patients 30 years or younger.

28 March 2022 in Joint Diseases and Related Surgery
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Journal Article
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SRSanjiv Rampal
Sanjiv Rampal
AJAshish Jaiman
Ashish Jaiman
MTMehmet Ali Tokgoz
Mehmet Ali Tokgoz
GAGayathri Arumugam
Gayathri Arumugam
SSSureshan Sivananthan
Sureshan Sivananthan
MMMaziar Mohaddes
Maziar Mohaddes
Joint Diseases and Related Surgery (JDRS), the official journal of the Turkish Joint Diseases Foundation, is an international, peer-reviewed, immediate open access journal. All published articles in JDRS has been free for everyone, without embargo, since 1990.