In the present study, the effect of entropy production on electromagnetohydrodynamic hybrid nanofluid (Gold- alumina/Blood) flow owing to a rotating disk in the presence of an electric field and thermal radiation are investigated. By applying the self-similarity variables, the PDE is converted into ODEs. After that, by using the Homotopy Perturbation Method (HPM). The Homotopy Perturbation Method (HPM) yields more efficient and reliable results than the numerical (Runge-Kutta) approach. To highlight their physical significance, a unique characteristic graph is shown for the profiles of temperature, velocity, and entropy generation, along with an appropriate explanation. The main findings are the velocity profile is increased by amplifying the Weissenberg, while the porosity and magnetic field reduce it. The temperature profile enhances due to rise in the electric field and radiation parameters. Entropy generation and Bejan number profiles increase due to an increment in Weissenberg and Brinkman numbers. The focus of this research can be applicable in the treatment of atherosclerosis without surgery, as well as to minimize medical expenditures and post-surgical problems. It has far-reaching significance in the treatment of cancers and diseases, as well as the elimination of blood clots.

The proficiency of hybrid nanoparticles in increasing heat transfer has impressed many researchers to further analyze the working of those fluids. In the current study, the impact of entropy generation on EMHD hybrid nanofluid (copper-alumina) flow over a rotating disk in the presence of the porous medium, Darcy‐Forchheimer, heat generation, viscous dissipation, and thermal radiation. By applying the self-similarity variables, the partial differential equations are converted into ordinary differential equations. After that, the dimensionless equations are numerically solved by using the Runge-Kutta technique, and also the comparison is done between the numerical technique (R-K method) and the homotopy perturbation method (HPM) where HPM yields a more effective and dependable conclusion. To highlight their physical significance, unique characteristic graphs are shown for the profiles of velocity, temperature, and entropy generation, along with a suitable explanation. The hybrid nanofluid velocity decreases with larger values of the magnetic parameter, but the velocity profile increases with the higher electric field. It is observed that both skin friction and nusselt number are increasing function of magnetic parameter and electric field parameter.