Ailiang Chen

Dr. Ailiang Chen

Institute of Quality Standard & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, China
orcid

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2015 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
ACAiliang Chen
Ailiang Chen
SYShuming Yang
Shuming Yang

17 December 2014 in Scientific Reports
Verified
Journal Article
Open access
JLJinchuan Liu
Jinchuan Liu
WBWenhui Bai
Wenhui Bai
SNShucao Niu
Shucao Niu
CZChao Zhu
Chao Zhu
SYShuming Yang
Shuming Yang
ACAiliang Chen
Ailiang Chen
Gold nanoparticle (AuNP) based colorimetric aptasensor have been developed for many analytes recently largely because of the ease of detection, high sensitivity, and potential for high-throughput analysis. Most of the target aptamers for detection have short sequences. However, the approach shows poor performance in terms of detection sensitivity for most of the long-sequence aptamers. To address this problem, for the first time, we split the 76[emsp14]mer aptamer of 17[bgr]-estradiol into two short pieces to improve the AuNP based colorimetric sensitivity. Our results showed that the split P1 + P2 still retained the original 76[emsp14]mer aptamer's affinity and specificity but increased the detection limit by 10-fold, demonstrating that as low as 0.1[emsp14]ng/mL 17[bgr]-estradiol could be detected. The increased sensitivity may be caused by lower aptamer adsorption concentration and a lower affinity to the AuNPs of a short single-strand DNA (ssDNA) sequence. Our study provided a new way to use long-sequence aptamers to develop a highly sensitive AuNP-based colorimetric aptasensor.

29 May 2015 in Environmental Toxicology and Chemistry
Verified
Journal Article
Closed access
PDF file
WBWenhui Bai
Wenhui Bai
CZChao Zhu
Chao Zhu
JLJinchuan Liu
Jinchuan Liu
MYMengmeng Yan
Mengmeng Yan
SYShuming Yang
Shuming Yang
ACAiliang Chen
Ailiang Chen

15 February 2024 in Food Chemistry
Verified
Journal Article
Closed access
JCJiaci Chen
Jiaci Chen
JZJuan Zhang
Juan Zhang
NWNan Wang
Nan Wang
BXBin Xiao
Bin Xiao
XSXiaoyun Sun
Xiaoyun Sun
ACAiliang Chen
Ailiang Chen

1 March 2016 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
MYMengmeng Yan
Mengmeng Yan
WBWenhui Bai
Wenhui Bai
CZChao Zhu
Chao Zhu
YHYafei Huang
Yafei Huang
JYJiao Yan
Jiao Yan
ACAiliang Chen
Ailiang Chen

1 February 2018 in Journal of Hazardous Materials
Verified
Journal Article
Closed access
CZChao Zhu
Chao Zhu
GZGuilan Zhang
Guilan Zhang
YHYafei Huang
Yafei Huang
SYShuming Yang
Shuming Yang
SRShuyue Ren
Shuyue Ren
ACAiliang Chen
Ailiang Chen