A placebo-controlled study evaluated the clinical efficacy and safety of a commercially available cannabidiol (CBD) oral formulation as an adjunctive treatment for pain management for feline chronic gingivostomatitis (FCGS). CBD was included in a multimodal treatment routinely performed on client-owned cats with FCGS that were submitted to dental extractions. Twenty-two cats were consecutively included in the study. The first group was treated using a fixed dosage of 4 mg per cat every 12 h for 15 consecutive days, and the second received a placebo of similar features. Treatments began 2 h before dental extractions. Pain and disease severity were assessed at days 0 and 15 using the Composite Oral Pain Scale (COPS-C/F) and the Stomatitis Disease Activity Index score (SDAI). Weight, vital and biochemistry parameters, and analgesic reinforcement needs were also registered at the same time points. In the treated cats, blood was collected after 4, 8, and 12 h to determine CBD serum concentrations using ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS/MS). After data analysis using mixed models, a significant improvement in the SDAI scores of cats medicated with CBD was found. The protocol is safe since severe adverse effects and biochemical changes were not observed during the treatment period. This study suggests that the cats benefited from this treatment.

Oral and dental diseases are among the most common problems observed in small-breed dogs. The Yorkshire Terrier is one of the breeds that most often exhibits oral disease at an early stage, namely, periodontal disease as well as persistent deciduous teeth. The present study aims to describe and analyze primary dental–skeletal anomalies in Yorkshire Terrier dogs aged <2 years, observed in referral dentistry practices, between 2015 and 2024. Dogs with full-mouth dental radiographs and charting were included. Dental agenesis, malocclusions and crowding, persistent deciduous teeth, and shape anomalies were the most frequent findings. Agenesis was mostly encountered in mandibular third molars (90% of dogs, 53 of 183 missing teeth) and was significantly associated with the presence of fused roots in the second molars ( P = .0006). Shape abnormalities included microdontia, dilaceration, and fused roots. The previously described bilateral carnassial tooth malformations were observed in 10% of individuals. Eruption anomalies were significantly associated with malocclusion ( P = .008). Although these results were based on a convenience sample referred for dental consultation and cannot be extrapolated for the overall population, they show a tendency, which can be a reflection of the dogs’ reduced size. Hypodontia and oligodontia in these breeds are possibly an advantage, which can decrease occurrence and severity of malocclusions.