Gregory Caputo

Dr. Gregory Caputo

Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
orcid

Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
13 January 2009 in Chemistry – A European Journal
Verified
Journal Article
Closed access
PDF file
KKKenichi Kuroda
Kenichi Kuroda
Gregory CaputoGregory Caputo
Gregory Caputo
WDWilliam F. DeGrado
William F. DeGrado

30 March 2007 in Science
Verified
Journal Article
Closed access
PDF file
HYHang Yin
Hang Yin
JSJoanna S. Slusky
Joanna S. Slusky
BBBryan Berger
Bryan Berger
RWRobin S. Walters
Robin S. Walters
GVGaston Vilaire
Gaston Vilaire
WDWilliam F. DeGrado
William F. DeGrado
A variety of methods exist for the design or selection of antibodies and other proteins that recognize the water-soluble regions of proteins; however, companion methods for targeting transmembrane (TM) regions are not available. Here, we describe a method for the computational design of peptides that target TM helices in a sequence-specific manner. To illustrate the method, peptides were designed that specifically recognize the TM helices of two closely related integrins (α IIb β 3 and α v β 3 ) in micelles, bacterial membranes, and mammalian cells. These data show that sequence-specific recognition of helices in TM proteins can be achieved through optimization of the geometric complementarity of the target-host complex.

3 August 2012 in Macromolecular Bioscience
Verified
Journal Article
Closed access
PDF file
KGKatherine A. Gibney
Katherine A. Gibney
ISIva Sovadinova
Iva Sovadinova
ALAnalette I. Lopez
Analette I. Lopez
MUMichael Urban
Michael Urban
ZRZachary Ridgway
Zachary Ridgway
KKKenichi Kuroda
Kenichi Kuroda

17 October 2012 in WIREs Nanomedicine and Nanobiotechnology
Verified
Journal Article
Closed access
PDF file
KKKenichi Kuroda
Kenichi Kuroda
Gregory CaputoGregory Caputo
Gregory Caputo

17 April 2017 in Bioconjugate Chemistry
Verified
Journal Article
Closed access
HTHaruko Takahashi
Haruko Takahashi
Gregory CaputoGregory Caputo
Gregory Caputo
SVSatyavani Vemparala
Satyavani Vemparala
KKKenichi Kuroda
Kenichi Kuroda

5 July 2013 in Macromolecular Bioscience
Verified
Journal Article
Closed access
PDF file
HTHaruko Takahashi
Haruko Takahashi
EPEdmund F. Palermo
Edmund F. Palermo
KYKazuma Yasuhara
Kazuma Yasuhara
Gregory CaputoGregory Caputo
Gregory Caputo
KKKenichi Kuroda
Kenichi Kuroda