Magnetic CuFe₂O₄ was prepared with the modified sol–gel method and used for enhanced peroxymonosulfate (PMS) activation and ofloxacin (OFL) degradation. The OFL could almost degrade within 30 min at a catalyst dosage of 0.66 g/L, PMS concentration of 0.38 mM, and initial pH of 6.53 without adjustment, using response surface methodology (RSM) with Box-Behnken design (BBD). In the CuFe₂O₄/PMS system, the coexisting substances, including CO₃²⁻, NO₃⁻, SO₄²⁻, Cl⁻ and humic acid, have little effect on the OFL degradation. The system also performs well in actual water, such as tap water and surface water (Mei Lake), indicating the excellent anti-interference ability of the system. The cyclic transformation between Cu(II)/Cu(I) and Fe(III)/Fe(II) triggers the generation of active radicals including SO₄^•−, •OH, •O₂⁻ and ¹O₂. The OFL degradation pathway, mainly involving the dehydrogenation, deamination, hydroxylation, decarboxylation and carboxylation processes, was proposed using mass spectroscopy. Moreover, the toxicity assessment indicated that the end intermediates are environmentally friendly. This study is about how the CuFe₂O₄/PMS system performs well in PMS activation for refractory organic matter removal in wastewater.

Background: Allergic rhinitis (AR) in children has become a common clinical allergic disease, the incidence of which is increasing in pediatric. The side effects of the drug cause parents to worry about the health of their child. However, a large number of current clinical studies have shown that acupuncture therapy is effective in treating children with AR. Therefore, this systematic review aims to explore the safety and effectiveness of acupuncture in the treatment of AR in children. Methods: We will conduct a comprehensive literature search in Medline, PubMed, Cochrane Database of Systematic Reviews, Embase, Chinese Biomedical Literatures Database (CBM), China National Knowledge Infrastructure (CNKI), Wang Fang Database (WF), Chinese Scientific Journal Database (VIP) from inception to November 2020 without any language restriction. In addition, we will retrieve the unpublished studies and the references of initially included literature manually. Reviewers will identify studies, extract data, and assess the quality independently. The outcomes of interest include: total effective rate; the total nasal symptom score; Rhinitis quality of life questionnaire (RQLQ); Visual Analog Scale (VAS); Laboratory inspection indicators: the level of IgE, IL6, IL10 or TNF-α; Recurrence rate; adverse events. Randomized clinical trials will be collected, methodological quality will be evaluated using the Cochrane risk-of-bias assessment tool, and the level of evidence will be rated using the Grading of Recommendations, Assessment, Development and Evaluation approach. Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity test will be conducted between the studies, P < .1 and I ² > 50% are the thresholds for the tests. We will utilize the fixed effects model or the random effects model according to the size of heterogeneity. Results: The results of this systematic review will provide a synthesis of current evidence of AR in children. We will report this result shortly. Conclusion: This study will explore whether or not acupuncture therapy can be used as one of the non drug therapies to prevent or treat allergic rhinitis in children. Trial registration number: INPLASY2020110053.

Mercury ions (Hg²⁺), a heavy metal contaminant of strong biotoxicity, pose a serious threat to ecosystems and human health in aquatic environments. Developing highly sensitive and specific detection methods is therefore of great importance. This study presents a novel label-free fluorescent biosensor for Hg²⁺ by ingeniously coupling target-induced aptamer switching with rolling circle amplification (RCA). Upon Hg²⁺ binding, the conformational change releases a sequestered primer to initiate RCA, generating G-quadruplex-rich DNA products that produce a strong “turn-on” signal with N-methylmesoporphyrin IX (NMM). Under optimized conditions, the assay exhibits excellent linearity from 10 to 1000 nM with a detection limit of 3.2 nM, along with high selectivity over competing metal ions. Validation using spiked environmental water samples yielded accurate and reproducible recoveries in the range of 93.8% to 106.0%. With its operational simplicity, high sensitivity, and robust performance in complex matrices, this label-free strategy offers a reliable and promising platform for detecting Hg²⁺ in environmental waters.