The scattered, isolated, and closed nature of rural settlements in northwest Sichuan is a constraint on the high-quality development of rural areas. Determining the spatial differences and driving forces of rural settlements in this area is the essential prerequisite for promoting rural revitalization. In this paper, the methods of the nearest neighbor index, the Voronoi diagram, and the Geodetector are used to analyze the spatial distribution characteristics of rural settlements and explore the driving factors of their spatial differences. The key findings are as follows. (1) The rural settlements exhibit the feature of “an extensive dispersion with localized concentrations”. The spatial distribution is in the shape of dots, strips, and branches along the river valley. (2) The number and land use scale of rural settlements decreases from east to west. The spatial differences in settlement morphology have a clear feature that the settlement morphology along the river and road is more complex, while the settlement morphology in the plateau area and the river valley is relatively regular. (3) Mountain disasters and arable land resources have the greatest impact on the spatial differences of the settlements. The location and form of the settlements are greatly affected by the altitude and accumulated temperature, and the settlement scale is significantly affected by the traffic conditions and the scenic spots. The mutually reinforcing role of the driving factors is remarkable, especially the reinforcing effects of the enhancement between the arable land resources and other factors. The research results provide data support for the reconstruction, improvement, and high-quality development of rural settlements in this region.

Ecosystem service value (ESV) is a key indicator for evaluating ecosystem services. Thus, a unique quantitative assessment instrument that comprehensively and objectively evaluates ESV is of great significance for protecting regional ecosystems and achieving sustainable development. Based on data for meteorology, hydrology, soil use, and land use, this paper comprehensively employs the InVEST model, spatial autocorrelation, and geographic detectors to study the spatiotemporal characteristics and driving forces of spatial variations in ESV in the upper reaches of the Minjiang River. The results indicate the following: (1) The ecosystem service capacity of the study area has continuously improved, with the ecosystem service value (ESV) increasing by USD 4.078 billion over 20 years. Soil conservation has made the most significant contribution to the growth of ESV, accounting for over 85%. (2) The distribution of ESV exhibits a “lower in the northwest, higher in the southeast” trend. The Moran’s I value for each year exceeds 0.7, indicating characteristics of High–High and Low–Low aggregation. (3) Slope plays a dominant role in causing the spatial differentiation of ESV, contributing 30.9%. Slope is followed by HAI at 19.7% and the urbanization rate at 16.8%. Rainfall has the least impact at 4%. (4) The results from the multi-factorial interactions reveal that all factors experience synergistic enhancement effects when interacting. The spatiotemporal differentiation of ESV is the result of multiple factors acting in conjunction, underscoring the importance of coordinated efforts in ecological restoration and comprehensive environmental management in the upper reaches of the Minjiang River. The methodology of this research could be applied to assess the impact of natural changes and human activities on ESV. The findings offer theoretical support for regional resource and environmental management, as well as ecological compensation decision making.