Contemporary research concerning surfactant science and technology comprises a variety of requirements relating to the design of surfactant structures with widely varying architectures to achieve physicochemical properties and dedicated functionality. Such approaches are necessary to make them applicable to modern technologies, such as nanostructure engineering, surface structurization or fine chemicals, e.g., magnetic surfactants, biocidal agents, capping and stabilizing reagents or reactive agents at interfaces. Even slight modifications of a surfactant’s molecular structure with respect to the conventional single-head–single-tail design allow for various custom-designed products. Among them, multicharge structures are the most intriguing. Their preparation requires specific synthetic routes that enable both main amphiphilic compound synthesis using appropriate step-by-step reaction strategies or coupling approaches as well as further derivatization toward specific features such as magnetic properties. Some of the most challenging aspects of multicharge cationic surfactants relate to their use at different interfaces for stable nanostructures formation, applying capping effects or complexation with polyelectrolytes. Multiheaded cationic surfactants exhibit strong antimicrobial and antiviral activity, allowing them to be implemented in various biomedical fields, especially biofilm prevention and eradication. Therefore, recent advances in synthetic strategies for multiheaded cationic surfactants, their self-aggregation and performance are scrutinized in this up-to-date review, emphasizing their applications in different fields such as building blocks in nanostructure engineering and their use as fine chemicals.

The removal of graffiti or over-painting requires special attention in order to not induce the surface destruction but to also address all of the important eco-compatibility concerns. Because of the necessity to avoid the use of volatile and toxic petroleum-based solvents that are common in cleaning formulations, much attention has recently been paid to the design of a variety of sustainable formulations that are based on biodegradable raw materials. In the present contribution we propose a new approach to graffiti cleaning formulations that are composed of newly synthesized green solvents such as esterified plant oils, i.e., rapeseed oil (RO), sunflower oil (SO), or used cooking oil (UCO), ethyl lactate (EL), and alkylpolyglucosides (APGs) as surfactants. Oil PEG-8 ester solvents were synthesized through the direct esterification/transesterification of these oils using monobutyltin(IV) tris(2-ethylhexanoate) and titanium(IV) butoxide catalysts under mild process conditions. The most efficient formulations, determined by optimization through the response surface methodology (RSM) was more effective in comparison to the reference solvents such as the so-called Nitro solvent (denoting a mixture of toluene and acetone) and petroleum ether. Additionally, the optimal product was found to be effective in removing graffiti from glass, metal, or sandstone surfaces under open-field conditions in the city of Wrocław. The performed studies could be an invaluable tool for developing future green formulations for graffiti removal.

Water-in-oil (w/o) nanoemulsions stabilized with amino acid surfactants (AAS) are one example of nanotechnology detergents of the “brush on, wipe off”-type for removing graffiti coatings from different sensitive surfaces. The high-pressure homogenization (HPH) process was used to obtain the nanostructured fluids (NSFs), including the non-toxic and eco-friendly components such as AAS, esterified vegetable oils, and ethyl lactate. The most effective NSF detergent was determined by response surface methodology (RSM) optimization. Afterwards, several surface properties, i.e., topography, wettability, surface free energy, and the work of water adhesion to surfaces before and after their coverage with the black graffiti paint, as well as after the removal of the paint layers by the eco-remover, were determined. It was found that the removal of graffiti with the use of the NSF detergent is more dependent on the energetic properties and microporous structure of the paint coatings than on the properties of the substrates on which the layers were deposited. The use of NSFs and knowledge of the surface properties could enable the development of versatile detergents that would remove unwanted contamination from various surfaces easily and in a controlled way.

This review describes a process design concept suitable for the fine and specialty chemicals sector. Experimental design and optimization methodologies are powerful tools for developing and improving a wide range of products, processes, and engineering systems. The research articles thoroughly analyzed in this review demonstrate that, regardless of the analytical techniques employed or the specific processes used in the fabrication of fine and specialty chemicals, the systematic implementation of the Design of Experiments and Response Surface Methodology consistently enables the development of high-quality and reproducible outcomes. Across all the studies discussed, comparing newly developed or modified processes with conventional approaches, the application of statistically designed experiments and structured multivariate analysis resulted in significant improvements in key performance indicators. These include increased product yield, reduced process times, enhanced purity, and more precise control over the targeted functional properties of specialty and fine chemicals. Good examples that illustrate the above problem are three studies supported by data from our previously published work and our current research project, in which experimental design and process optimization play major roles in obtaining valuable nanostructured materials. These case studies—rational liquid-in-liquid nanodispersions (ND) for ecological graffiti-coating detergents, solid-in-solid nanodispersions for functionalized sustainable cementitious composites, and solid-in-liquid multicharge cationic surfactant-capped silver nanoparticles (AgNPs)—are deliberately selected to illustrate how the same systematic design and optimization principles can be applied across distinct types of dispersed systems. Together, they demonstrate a coherent methodological progression from formulation to functional material development, highlighting the versatility of this approach across different material states and application domains. The findings of this review provide a solid foundation for the optimized manufacture of novel custom-designed nanoproducts.