It is well-established that cardiovascular disease and depression are highly comorbid. This study aimed to assess the possible role of the NOD-like receptor protein 3 (NLRP3) inflammasome pathway and the high-sensitivity C-reactive protein (hsCRP) in patients with incident myocardial infarction in the presence or absence of depression. Sixty-eight consecutive patients with incident ST-elevation myocardial infarction and twenty healthy subjects were included. The patients were assessed using the Structured Clinical Interview for DSM-5 Disorders—Clinician Version during their 1–4-day-long hospitalization and were divided into two groups: with and without comorbid depression. Blood samples for the determination of NLRP3, interleukin-18 (IL-18), interleukin-1β (IL-1β), and hsCRP levels were analyzed using ELISA. NLRP3, IL-1β, IL-18, and hsCRP levels were significantly higher in myocardial infarction patients compared to the healthy group (p = 0.02, p < 0.001, p < 0.001, and p < 0.001, respectively). No significant difference was found between the myocardial groups with and without depression. However, in the logistic regression analysis, the NLRP3 variable in myocardial infarction patients was found to have a significant contribution to the likelihood of depression (p = 0.015, OR = 1.72, and CI = 1.11–2.66). The likelihood of depression is associated with increasing NLRP3 levels in myocardial infarction patients. However, this potential role should be further explored in a larger sample.

Antiarrhythmic Properties of Beta Blockers: Focus on Nebivolol - International Journal of the Cardiovascular Academy

Objective: Premature ventricular complexes (PVCs) are common arrhythmias and catheter ablation (CA) is the major treatment in patients with PVCs. In this study, we aimed to share our experience on PVCs patients who had undergone CA. Patients and Methods: We investigated consecutive patients who had undergone CA because of PVCs between January 2015 and March 2021 in a single centre arrhythmia unit. Patients’ characteristics, rhythm Holter recordings, echocardiography results and CA outcomes were noted. Patients were followed up for 22.3±3.7 months. Descriptive statistics were used to demonstrate features of study patients. Results: Study population consisted of 645 patients; mean age was 51 ± 4.14 and 372 (57.7%) were male. Arrhythmia originated from the right ventricular outflow tract in 279 (46.6 %) patients, coronary cusps in 161 (26.9 %) patients, left ventricle summit in 50 (8.3%) patients and inside of the right or left ventricle in remaining patients. Sustained procedural success was achieved in 526 (88.1 %) patients. Recurrence was observed in 46 (6.7%) patients during follow-up. Major complication occurred in two patients (one procedural mortality due to coronary artery injury and one tamponade). Conclusion: Premature ventricular contraction ablation can be utilized safely with high success rate. Most PVCs originate from the right or left ventricular outflow tract.

Objective: Non-selective adrenergic alpha-1 antagonists have been shown to reduce arterial stiffness. Our aim is to assess the effects of a selective adrenergic alpha-1 antagonist on arterial stiffness, namely silodosin. Patients and Methods: This prospective study was carried out on 20 patients with recently diagnosed benign prostatic hyperplasia (BPH). International Prostate Symptom Score (IPSS) calculation, arterial stiffness test with an oscillometric device, and uroflowmetry were performed prior to the planned silodosin medical treatment. After initial assessment, patients were given 8 mg of silodosin daily. Initial tests and calculations were repeated after 1 month of follow-up. Comparisons between baseline and control data were performed using the paired sample t-test and the Wilcoxon signed-rank test for normally and non-normally distributed data, respectively. Results: There was a significant reduction in the IPSS of patients after silodosin treatment (p < 0.001). There were statistically insignificant reductions in arterial stiffness and systolic blood pressure, and an increase in maximum flow rate (p = 0.314, p = 0.608, and p = 0.053, respectively). Conclusion: Silodosin is an effective drug to relieve BPH symptoms but does not have a statistically significant effect on neither blood pressure nor arterial stiffness.

Multidisipliner Kardiyoloji Yoğun Bakım Tanımı ve Teknik Özellikleri Servet Altay Kardiyoloji Yoğun Bakımda Fizik Muayene Esasları Sena Sert Şekerci Kardiyoloji Yoğun Bakımında İnvaziv Hemodinamik Ölçümler Songül Usalp Arter Kan Gazı Değerlendirme Ethem Yıldız Yoğun Bakımda Beslenme Esasları Hande Özportakal Hipo/Hiperglisemi ve Diyabetik Komalara Yaklaşım Seydahmet Akın Songül Aktaş Koroner Yoğun Bakımda Akut Koroner Sendrom Hastalarının Yönetimi Efe Yılmaz Muhammet Gürdoğan Akut Koroner Sendrom Mekanik Komplikasyonları Mustafa Ferhat Keten Akut Kalp Yetersizliği ve Kardiyojenik Şok Yusuf Bilen Akut Fulminan Miyokardit Ertan Ekici Havva Tuğba Gürsoy Takotsubo Kardiyomiyopatisi Melik Demir Yoğun Bakım Ünitesinde Ventriküler Taşikardilere Yaklaşım Gökay Taylan Supraventriküler Taşiaritmilere Yaklaşım Çağan Yıldırım Alper Kepez Digoksin İntoksikasyonu Tuğba Kayhan Altuner Akut Doğal Kapak Yetersizlikleri Semih Kalkan Akut Protez Kapak Patolojileri Mustafa Ozan Gürsoy Hipertansif Aciller Mehmet Murat Yiğitbaşı Hülya Çiçekçioğlu Akut Aortik Sendromlar Hasan Ali Sinoplu Ersan Oflar Pulmoner Emboli ve Kateter Bazlı Tedavi Yöntemleri Ümit Öztürk Halil Ataş İnotrop ve Vazopressör Ajanlar Mehmet Ali Astarcıoğlu Yoğun Bakımda Diürez ve Aldığı Çıkardığı Takibi Esasları Flora Özkalaycı Kaçar Burcu Candan Renal Replasman Tedavisi Serap Yadigar Elif Arı Bakır Kardiyorenal Sendrom Ferdi Karagöz İlhan Kurultak Yoğun Bakımda Terapötik Hipotermi Mustafa Ebik Kardiyak Travma Safa Özçelik Elektriksel Fırtınaya Yaklaşım Abdulkadir Uslu Perikardiyal Efüzyon ve Kardiyak Tamponad Kadriye Memiç Sancar Gamze Babur Güler Yoğun Bakımda Geçici Kalp Pili Uygulamaları Sedat Sakallı Veysel Özgür Barış Geçici Mekanik Destek Cihazları Ahmet Can Topçu Şeyhmus Külahçıoğlu Ventriküler Destek Cihazları Hakan Hançer Mehmet Kaan Kırali Kalp Nakli Sonrası Takip, Tedavi ve Hasta Yönetimi Mustafa Mert Özgür Antikoagülan ve Antiplatelet Tedavi Altında Kanamaya Yaklaşım Tuba Unkun Vasküler Giriş Yeri Komplikasyonları Doğancan Çeneli Kadir Bıyıklı TAVI Sonrası Komplikasyonlar Mehmet Aytürk Münevver Sarı Yoğun Bakımda Deliryum Yönetimi Mengühan Araz Altay Akut İskemik İnmeye Yaklaşım Ayşenur Önalan Erdem Gürkaş Akut Solunum Yetmezliğine Yaklaşım Nezihe Çiftaslan Gökşenoğlu Nalan Adıgüzel Yoğun Bakımda Enfeksiyonun Kontrol ve Önlenmesi İnşa Gül Ekiz İşcanlı Acil Bronkoskopi Barış Yılmaz Gökay Güngör Akut Respiratuar Distres Sendromu Temel Güner Esra Adıyeke Kardiyoloji Yoğun Bakımda Sedasyon ve Analjezi Münire Deniz Mustafa Emre Gürcü