Jefferson Lima de Santana

Mr. Jefferson Lima de Santana

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
10 August 2023 in Sports
Verified
Journal Article
Open access
PDF file
LSLarissa Christine Vieira Santos
Larissa Christine Vieira Santos
Felipe J. AidarFelipe J. Aidar
Felipe J. Aidar
RVRodrigo Villar
Rodrigo Villar
Gianpiero GrecoGianpiero Greco
Gianpiero Greco
JSJefferson Lima de Santana
Jefferson Lima de Santana
WJWalderi Monteiro Da silva junior
Walderi Monteiro Da silva junior
Background: Paralympic powerlifting (PP) is performed on a bench press, aiming to lift as much weight as possible in a single repetition. Purpose: To evaluate thermal asymmetry and dynamic force parameters with 45 and 80% 1 Repetition Maximum (1 RM) in PP athletes. Methods: Twelve elite PP male athletes were evaluated before and after a training session regarding skin temperature (thermography) and dynamic force indicators (Average Propulsive Velocity-MPV, Maximum Velocity-VMax, and Power). The training consisted of five series of five repetitions (5 × 5) with 80% 1 RM. The force indicators and dynamics before and after (45% 1 RM) were evaluated in series “1” and “5” with 80% 1 RM. Results: The temperature did not present asymmetry, and there were differences between the moment before and after. In MPV, Vmax, and Power, with 45% 1 RM, there were differences both in asymmetry and in moments (p < 0.005). With 80% 1 RM, asymmetry was observed, but no differences between moments (p < 0.005). Conclusion: No thermal asymmetry was observed. There were reductions in MVP and VMax at 45 and 80% 1 RM but without significant differences between time points (before and after). However, there was asymmetry in the moments before and after within a safety standard, where Paralympic powerlifting was safe in terms of asymmetries.

19 May 2023 in Heliyon
Verified
Journal Article
Open access
RSRafael Luiz Mesquita SOUZA
Rafael Luiz Mesquita SOUZA
Felipe J. AidarFelipe J. Aidar
Felipe J. Aidar
RVRodrigo Villar
Rodrigo Villar
Gianpiero GrecoGianpiero Greco
Gianpiero Greco
Leonardo Dos SantosLeonardo Dos Santos
Leonardo Dos Santos
Stefania CataldiStefania Cataldi
Stefania Cataldi
Powerlifting competitions require consistent and symmetric lifting of heavy loads and maximal effort, in which, asymmetric lifting results in trial invalidation. Symmetry during this very high intensity movement is determinant to athletes’ performance and success in competitions. This study aimed to compare the asymmetry between Conventional Powerlifting athletes (CP) and Paralympic (PP) athletes at intensities of 45 and 80% 1RM before and after a training session. Twenty-two male athletes (11 CP: 29.84 ± 4.21 and 11 PP: 30.81 ± 8.05 years old) participated in this study. Mean Propulsive Velocity (MPV), Maximum Velocity (Vmax) and Power during the concentric and eccentric phases were evaluated at 45%-1RM before and after a training session. For the intensity of 80%-1RM, MPV, Vmax and Power were measured in the first and last series (5 series of 5 repetitions: 5X5) of a training session. PP athletes demonstrated lower velocity and greater symmetry at 45%-1RM, but higher velocity and less asymmetry at 80%-1RM, when compared to CP. The data indicated that PP athletes tend to be slower at lower intensities, faster at higher intensities in absolute values, and have greater symmetry than CP.

24 September 2025 in Healthcare
Verified
Journal Article
Open access
PDF file
Dihogo de MatosDihogo de Matos
Dihogo de Matos
JSJefferson Lima de Santana
Jefferson Lima de Santana
Felipe J. AidarFelipe J. Aidar
Felipe J. Aidar
SCStephen Cornish
Stephen Cornish
GGGordon G. Giesbrecht
Gordon G. Giesbrecht
RVRodrigo Villar
Rodrigo Villar
Background: As we age, our autonomic function declines, resulting in altered autonomic balance during postural transitions. These changes can affect the dynamic interplay between sympathetic and parasympathetic modulation, compromising short-term compensatory responses to active standing. Objectives: This study aimed to compare heart rate variability (HRV) at baseline, cardiac parasympathetic modulation (CPM), and cardiac baroreflex gain (CRG) between younger adults (YA) and older adults (OA) following active standing orthostatic stress. A secondary objective was to analyze the incidence of orthostatic intolerance (OI) symptoms. Methods: Participants (n = 76) completed sit-to-stand and lie-to-stand maneuvers with continuous beat-to-beat blood pressure and heart rate (HR, electrocardiogram). HRV at baseline was analyzed in both time and frequency domains. CPM was measured by the HR 30:15 ratio on standing. CBG was determined as the ratio of HR and SBP changes (ΔHR/ΔSBP) at specific phase time points (30 s, 60 s, 180 s, and 420 s). Results: At baseline, OA showed reduced Standard Deviation of RR intervals (SDRR), Root Mean Square of Successive Differences (RMSSD), low-frequency (LF), and high-frequency (HF) power, and elevated LF/HF ratio (all p < 0.05), indicating a shift toward sympathetic dominance. During active standing orthostatic stress, OA demonstrated a lower HR30:15 ratio and CBG in later phases (phases 2–4) (all p < 0.05). Also, OA reported more symptoms (14%) of OI than YA (0%) (p = 0.041). Conclusions: These findings indicate that older adults have impaired autonomic function characterized by reduced HRV, CPM and CBG responses. These impairments lead to diminished autonomic regulation under active-standing orthostatic stress and a higher incidence of OI symptoms.

13 October 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
Dihogo de MatosDihogo de Matos
Dihogo de Matos
JSJefferson Lima de Santana
Jefferson Lima de Santana
Felipe J. AidarFelipe J. Aidar
Felipe J. Aidar
SCStephen Cornish
Stephen Cornish
GGGordon G. Giesbrecht
Gordon G. Giesbrecht
RVRodrigo Villar
Rodrigo Villar
Background: The cardiovascular system of older adults is significantly impacted by aging, contributing to blood pressure (BP) dysregulation, particularly during postural transitions. This study compared the short-term cardiovascular compensatory responses of younger adults (YA) and older adults (OA) during sit-to-stand and lie-to-stand. Methods: Participants underwent two active standing orthostatic stress tests, involving 5 min of sitting or 10 min of lying, followed by up to 7 min of standing. Beat-to-beat cardiovascular parameters were assessed using a Finometer (Finapres Medical Systems). Systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR), and HR were measured at baseline, immediately on standing, and throughout four specific phases after standing: phase 1 (0–30 s), phase 2 (30–60 s), phase 3 (60–80 s), and phase 4 (300–420 s). CO-SVR matching was evaluated to assess BP regulation timing. Results: Compared to YA, OA exhibited higher SBP, DBP, MAP, and SVR but lower HR, CO, and SV at baseline. Immediately on standing, OA experienced a greater drop in SBP, DBP, MAP, and SVR, blunted HR, reduced CO, and higher SV. The short-term compensatory responses were delayed (30–60 s), particularly in lie-to-stand, due to a transient CO and SVR mismatch observed in phase 1 and subsequent BP stabilization from phases 2–4. Conclusions: OA exhibited short-term compensatory cardiovascular dysregulation, particularly during the transition from a lying to a standing position.

14 July 2025 in Preprints.org
Verified
Preprint
Open access
PDF file
Dihogo de MatosDihogo de Matos
Dihogo de Matos
JSJefferson Lima de Santana
Jefferson Lima de Santana
Felipe J. AidarFelipe J. Aidar
Felipe J. Aidar
SCStephen Cornish
Stephen Cornish
GGGordon G. Giesbrecht
Gordon G. Giesbrecht
RVRodrigo Villar
Rodrigo Villar
As we age, our autonomic function declines, resulting in altered autonomic balance during postural transitions. These changes can affect the dynamic interplay between sympathetic and parasympathetic modulation, compromising short-term compensatory responses to active standing. This study aimed to compare heart rate variability (HRV) at baseline, cardiac parasympathetic modulation (CPM), and cardiac baroreflex gain (CRG) between younger adults (YA) and older adults (OA) following active standing orthostatic stress. A secondary objective was to analyze the incidence of orthostatic intolerance (OI) symptoms. Participants completed sit-to-stand and lie-to-stand maneuvers with continuous beat-to-beat blood pressure and heart rate (HR, electrocardiogram). HRV at baseline was analyzed in both time and frequency domains. CPM was measured by the ratio between HR at the 30th beat and the 15th beat (HR 30:15) on standing. CBG was determined as the ratio of HR and SBP changes (ΔHR/ΔSBP) at specific phase time points (30s, 60s, 180s, and 420s). At baseline, OA exhibited reduced Standard Deviation of RR intervals (SDRR), Root Mean Square of Successive Differences (RMSSD), low-frequency (LF), and high-frequency (HF) power, and elevated LF/HF ratio, indicating a shift toward sympathetic dominance. During active standing orthostatic stress, OA demonstrated higher CPM and lower CBG in later phases (phases 2-4). Also, OA reported more symptoms (14%) of OI than YA (0%). In conclusion, these findings indicate that older adults have impaired autonomic function characterized by reduced HRV, higher CPM, and lower CBG. These impairments lead to diminished autonomic regulation under active-standing orthostatic stress and a higher incidence of OI symptoms.

Dihogo de MatosDihogo de Matos
Dihogo de Matos
JSJefferson Lima de Santana
Jefferson Lima de Santana
AMAsher Mendelson
Asher Mendelson
TDTodd Duhamel
Todd Duhamel
RVRodrigo Villar
Rodrigo Villar
Older adults often experience episodes of a sudden drop in blood pressure when standing, known as orthostatic hypotension (OH). OH is associated with an increased risk of life-threatening health problems, falls, and death. Although OH has been studied in older adults, the integrated dynamic autonomic and cardiovascular regulation during postural transitions in older adults with frailty remains scarce and poorly understood. The primary aim of this systematic review is to determine the association between how active (e.g., lie-to-stand) and passive (head-up tilt) postural transitions affect the dynamic integrated autonomic and cardiovascular regulatory responses, comparing older adults with different levels of frailty (non-frail, pre-frail, or frail). A second aim is to perform a meta-analysis to compare autonomic and cardiovascular responses during active postural transitions in non-frail, pre-frail, and frail older adults. The systematic review will be outlined according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. The meta-analysis will generate estimates of the comparative autonomic and cardiovascular responses after active postural transitions in adults who are non-frail, pre-frail, and frail. This systematic review will provide critical information on how integrated dynamic autonomic and cardiovascular regulation occurs during postural transitions in older adults with different frailty statuses.