NiFeS nanosheet array on Ni foam (NiFeS/NF) behaves as a superb bifunctional electrocatalyst for overall seawater splitting, attaining a commercially demanded current density of 500 mA cm ⁻² at a low cell voltage of 1.85 V with robust stability.

Multicomponent solid-solution metal sulfides (SSMSs) have triggered growing research interest on account of their outstanding electrochemical activity and fascinating theoretical capacity. The main bottlenecks for the development of SSMS, however, lie in the sluggish reaction kinetics, together with the severe electrode pulverization and inactivation caused by tremendous volume change upon fast Na⁺ de-intercalation. Engineering intriguing electrode structures with desirable reaction kinetics is imperative for facilitating the sodium storage capability of SSMSs. Herein, a bimetallic solid-solution NiCo₂S₄ nanoparticles tightly anchored on a green and renewable biomass-juncus-derived three-dimensional (3D) interconnected reticular carbon-tube (NiCo₂S₄/JDC) was synthesized through a facile combustion treatment followed by in situ sulfuration. With the aid of a protogenos interconnected 3D tubular carbon network, the NiCo₂S₄/JDC composites acquire affluent active sites and porous channels, adequate electrode/electrolyte interface areas, and superior conductivity, thereby achieving high sodium-storage capacity and excellent rate capability. Particularly, an outstanding cyclability with a competitive capacity of 231.7 mA h g⁻¹ after 3200 cycles at 20.0 A g⁻¹ significantly outperforms the majority of the reported NiCo₂S₄-based anode hosts so far. Meanwhile, a string of the ex situ characterization technique further discloses the sodium storage reactions of NiCo₂S₄/JDC on account of intercalation and conversion reactions. The quantitative kinetics analysis combined with density functional theory fully unraveled that the NiCo₂S₄/JDC composites possess more remarkable surface-controlled capacitive features, larger Na⁺ diffusion coefficient, and higher Na⁺ adsorption energy than the corresponding monometallic sulfides NiS/JDC and CoS/JDC during the charge–discharge process.

Under ambient conditions, using low concentration NO (1%), ultrahigh nitrate formation rates in a two-electrode system can be achievedviathe eCOR-NOOR. The structure changes of electrode materials under real reaction conditions are revealed.

Colorectal cancer is a malignant tumor of the colon or rectum, with approximately 150,000 new cases each year. Current treatment strategies, such as surgery, chemotherapy, radiotherapy, and immunotherapy, face challenges ranging from cancer recurrence, drug resistance to significant toxicity. Therefore, these patients urgently need more effective treatments. Ferroptosis, a novel form of cell death characterized by iron-dependent lipid peroxidation, has emerged as a promising new approach for treating colorectal cancer. Inactivation of phospholipid hydroperoxide glutathione peroxidase (GPX4) or the cysteine/glutamate antiporter SLC7A11 leads to the depletion of cellular glutathione (GSH), resulting in lipid peroxidation and subsequent ferroptosis. Here, we found that CDH17 and GUCY2C are co-overexpressed in colorectal cancer cells and developed a bispecific antibody-drug conjugate (BsADC) targeting CDH17 and GUCY2C, conjugated with the ferroptosis inducer RSL3 (a GPX4 inhibitor). Experimental results showed that, compared to monoclonal antibody ADCs, BsADC exhibits better binding and internalization activities, and could inhibit tumor cell proliferation more effectively. Moreover, the BsADC displayed an advantageous safety profile in mice. These findings suggest that the CDH17-GUCY2C BsADC, which induces ferroptosis in tumor cells, could be a promising new treatment for colorectal cancer.