Background: Calcified coronary lesions can cause stent under-expansion, malapposition, and polymer degradation, hence increasing the risk of adverse clinical outcomes. Percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) has been used regularly to improve outcomes. Our primary aim was to evaluate the clinical efficacy of IVUS-guided PCI in calcified coronary lesions. Methods: From August 2018 to December 2021, we prospectively included 300 patients in the CAPIRO study (CAlcified plaque in patients receiving Resolute Onyx^®) at three educational hospitals in Jeonbuk Province. We studied 243 patients (265 lesions) who were followed up for over a year. Based on coronary calcification by IVUS analysis, the patient population was categorized into two groups (Group I: non/mild calcification; Group II: moderate/severe calcification (maximum calcium arc >180° and calcium length > 5 mm)). One-to-one Propensity Score Matching was used to match the baseline characteristics. The stent expansion rate was analyzed by recent criteria. The primary clinical outcome was Major Adverse Cardiac Events (MACE), which included Cardiac death, Myocardial Infarction (MI), and Target Lesion Revascularization (TLR). Results: After follow-up time, the MACE rate in Group I was 1.99%, comparable to Group II’s 1.09% (p = 0.594). The components of MACE did not significantly differ between the two groups. Based on absolute MSA or MSA/MVA at MSA site criteria, the stent expansion rate in Group II was lower than that of Group I. Nevertheless, based on recent relative criteria, the stent expansion rate in both groups was comparable. Conclusions: After more than a year of follow-up, IVUS-guided PCI in moderate/severe calcification lesions was associated with good clinical outcomes, which was comparable with non/mild calcification lesions. Future studies with a larger sample size and a more extended follow-up period are required to clarify our findings.

Background : Left ventricular (LV) pseudoaneurysm (PSA), also referred to as contained LV wall rupture, is a clinically uncommon but potentially life-threatening condition that can occur after myocardial infarction or cardiac surgery. If the anatomic characteristics of LV PSA are not eligible for the transfemoral approach, percutaneous closure of LV PSA can be technically difficult and appropriate approach selection may contribute to procedural success. Case summary : An enlarging LV PSA was discovered in a 65-year-old man with Marfan syndrome and three prior cardiothoracic surgeries. Arterial access was not possible due to invagination of the previously placed surgical graft in the descending thoracic aorta. This was managed with a novel approach of simultaneous transseptal LV access and direct puncture of PSA through the chest wall followed by a vascular plug placement. Discussion : This case demonstrates that percutaneous LV PSA closure using a hybrid approach of transseptal and direct apical puncture is a feasible and effective alternative for high-risk surgical candidates, although the anatomic characteristics are unsuitable for the transfemoral approach.

Lee W, et al. Korean Circ J. 2025 Jul;55:e108. https://doi.org/10.4070/kcj.2024.0400

Rationale: Serotonin syndrome (SS), also referred to as serotonin toxicity, is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system, but often underdiagnosed due to its variable presentation. Patient concerns: A 46-year-old woman presented to the emergency department with complaints of fever, confused mental status with slurred speech, agitation. The patient also exhibited lower extremities weakness with spontaneous clonus. The physical examination revealed tachycardia and tachypnea. The patient was taking fluoxetine for depression disorder and anti-obesity medications including topiramate and phentermine. Initial laboratory finding demonstrated severe hypoxemia and rhabdomyolysis with renal dysfunction. Diagnoses: Spinal tap and brain magnetic resonance imaging showed no clues that could explain the patient’s neuromuscular symptoms. Based on the patient’s overall presentation and use of medications, a diagnosis of SS was made. However, the patient’s inpatient treatment was complicated by pulmonary thromboembolism (PTE) and stress-induced cardiomyopathy (SCM). Interventions: The patient was intubated and admitted to the intensive care unit for supportive care, including mechanical ventilation and hemodialysis. The patient received an intravenous benzodiazepine and vecuronium for controlling autonomic dysfunction and neuromuscular symptoms. Anticoagulation was also initiated promptly following the diagnosis of PTE. Outcomes: After intensive supportive care, she was discharged 1 month after admission with normalized left ventricular motion and systolic function. Lessons: This case highlights that SS should be considered as an etiology of unexplained episodes of altered mental status and neuromuscular abnormalities. Rarely, this condition can be complicated by multiple organ injury, involving conditions such as rhabdomyolysis, renal failure, SCM and PTE. Thus, physicians must be aware of the various and atypical manifestations of serotonin syndrome in order to avoid missing the diagnosis of a potentially fatal condition.