The transmission of zoonotic diseases through animal-derived food products poses a significant global public health challenge, with contaminated milk and meat serving as major transmission pathways. In Nepal, the growing consumption of these products has amplified the risk of foodborne illnesses, largely due to widespread bacterial contamination. This review systematically explores the prevalence, distribution, and public health significance of key bacterial pathogens- including Salmonella, Escherichia coli, Shigella, Staphylococcus aureus, Brucella, Bacillus cereus, Mycobacterium tuberculosis, and Campylobacter in Nepalese milk and meat products. The analysis identifies major contributing factors: inadequate hygiene and sanitation practices, weak regulatory frameworks, insufficient infrastructure, excessive antibiotic usage, and limited public awareness. The high levels of bacterial contamination, coupled with the emergence of antibiotic-resistant strains, underscore the urgency for strategic interventions. Recommended measures include strict enforcement of hygiene and sanitation standards, strengthening regulatory policies, enhancing infrastructure, comprehensive public education campaigns, and prudent antibiotic stewardship. Implementation of these strategies is imperative to improve food safety, protect public health, and mitigate the risks posed by bacterial zoonotic diseases in Nepal.

This case report documents the first confirmed outbreak of African swine fever (ASF) in a wild boar (Sus scrofa) in Nepal. The case was identified in a wild boar carcass found in Shuklaphanta National Park in February 2023. Post‐mortem findings, including splenomegaly, haemorrhagic lymph nodes and congested organs, were suggestive of ASF, which was confirmed by real‐time PCR. Epidemiological evidence indicates potential transmission from nearby ASF‐infected domestic pigs. This case underscores the critical need for rigorous biosecurity protocols, comprehensive surveillance and targeted wildlife management strategies to prevent further transmission between domestic pig and wild boar populations.

African swine fever (ASF) has emerged as a major threat to Nepal’s pig farming sector since its first outbreak in March 2022. The disease has caused significant declines in both the pig population and pork production, severely affecting rural communities reliant on pig farming for their livelihoods. ASF’s spread is facilitated by key risk factors, including swill feeding, informal cross-border trade, and poor on-farm biosecurity measures. Additionally, seasonal trends, particularly during the monsoon, exacerbate the spread of the disease, especially in areas with high pig density. Control efforts face numerous challenges, including limited veterinary infrastructure, inadequate surveillance systems, gaps in legislation, and a lack of awareness among farmers about biosecurity practices. This study presents a comprehensive analysis of ASF’s epidemiology in Nepal, exploring the disease’s socio-economic impact and identifying key control challenges. The paper provides targeted recommendations to improve veterinary services, strengthen surveillance systems, enforce biosecurity measures, and enhance cross-border cooperation. It also emphasizes the importance of fostering community engagement and developing effective policy frameworks to ensure long-term ASF prevention and control, ensuring a more resilient pig farming sector in Nepal.