This study explores the physicochemical changes provoked by the physical transmission of highly diluted (HD) solutions of Arnica montana extract on three receiver solutions differing by their pH. Three dilutions (potencies), one modest (D6), one very high (C30), and another ultra-high (C200) extract of A. montana, were used as a source of HD signal transfer. The HD signal transfer was enhanced by an initial knocking at the start of the experiment and then allowed to interact with the receiver solution for 24 h of exposure. The results confirmed the detectability of the HD signal transfer in solutions with different pH, the general effect of this signal on pH increase, the differential effect of the signal depending on the initial dilution level (potency), and the effect on the decrease in both the electrical voltage in water (ORP) and the conductivity. The overall findings of the study offer valuable new insights and suggest innovative approaches for further research, particularly in detecting the HD signal in solutions with varying pH levels, focusing on interactions with hydroxide and hydronium ions.