The use of UAVs equipped with sensors has gained prominence due to their efficiency, safety, and ability to provide detailed data for hard-to-reach inspections, allowing for more precise and integrated analyses. Despite their great potential, these technologies still face a significant gap in understanding the actual capabilities of each piece of equipment to identify different pathological manifestations on building façades, as well as their advantages and limitations. In this context, this study aimed to analyze the capabilities and limitations of RGB, thermal, and multispectral sensors embedded in UAVs for detecting pathologies on building façades, addressing gaps in understanding their advantages, limitations, and effectiveness in identifying different anomalies. To this end, four façades of a building were mapped using these sensors, focusing on capturing pathologies such as cracks, moisture stains, coating detachment, and the presence of moss. The methodology involved using a UAV equipped with high-resolution RGB sensors (with GSD ranging from 0.867 mm to 0.985 mm per pixel), thermal sensors (with GSD ranging from 6.13 mm to 8.72 mm per pixel), and multispectral sensors (with GSD ranging from 6.49 mm to 9.80 mm per pixel), followed by the processing and creation of façade orthophotos and the visual identification of each pathology found on each face. Multiple image overlaps were performed to ensure adequate coverage of the analyzed surfaces. As a quantitative result, it was observed that the RGB sensor was the most effective in identifying surface pathologies, while thermal and multispectral sensors, although placing a smaller quantity of pathologies, stood out in detecting subsurface pathologies, such as infiltration and internal cracks. Complementarily, it was observed that the integration and complementarity of these devices could be of the utmost importance for a more comprehensive and precise analysis of pathologies, showing that combining different types of sensors significantly contributes to a more complete and detailed mapping of façade conditions.