Fyaz M. D. Ismail completed his PhD in Physical Organic Chemistry in 1989 (Salford University with Professor Roger H. Bisby) and then went onto“green” the highly polluting Kelly process (by converting it from batch to flow; Monsanto Research Fellow at Reading University with Dr Neal Stuart Isaacs: High-Pressure Chemistry Unit). After a decade as a senior lecturer in Spectroscopy and Medicinal Chemistry (University of Hertfordshire), he became a subject leader at the School of Pharmacy (LJMU). His research interests include modulating free radical processes in disease by perfecting weakly active substance (inspired by natural products) into clinically useful medicines using rational drug design, especially natural products such as artemisinin and cryptolepine using NMR and DFT. For the last decade, he and his colleagues have used DFT, spectroscopic and spectrometric methods (ion mobility) to discover that 4-aminoquinoline drugs act at the heme Plasmodial receptor through hydrogen bonding interactions, followed by fast electron transfer and scission of the porphyrin ring and eventually causing Plasmodial death through ferroptosis. Currently, he is the section lead for: The synthesis of Natural Products at the Centre for Natural Product Discovery, LJMU, Liverpool