Juvenile delinquency is a pressing problem in the United States; the literature emphasizes the importance of early interventions and the role of the family in preventing juvenile delinquency. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, PudMed, and Scopus, we included 28 peer-reviewed articles in English between January 2012 and October 2022. We evaluated the existing literature regarding the risk factors, protective factors, and interventions related to juvenile delinquency. We searched articles that discussed reducing juvenile delinquency and recidivism in the U.S. and coded them into four overarching themes: ‘family conflict and dysfunction’, ‘neglect and maltreatment’, ‘individual and family mitigating factors’, and ‘family- and community-based interventions. We found that family conflict and dysfunction and neglect and maltreatment were two primary predictors of juvenile delinquency. Notably, higher academic achievement and strong and positive parental relationships were factors that protected against delinquency amongst at-risk youth. Interventions that yielded optimal efficacy in curbing recidivism included family-based interventions, specifically family therapy, and community-based interventions. Considering multi-dimensional factors that affect delinquent behaviors, interventions should consider the influence of family, peers, neighborhood, schools, and the larger community.