Due to its increasing incidence, skin cancer, and especially melanoma, is a serious health disease today. The high mortality rate associated with melanoma makes it necessary to detect the early stages to be treated urgently and properly. This is the reason why many researchers in this domain wanted to obtain accurate computer-aided diagnosis systems to assist in the early detection and diagnosis of such diseases. The paper presents a systematic review of recent advances in an area of increased interest for cancer prediction, with a focus on a comparative perspective of melanoma detection using artificial intelligence, especially neural network-based systems. Such structures can be considered intelligent support systems for dermatologists. Theoretical and applied contributions were investigated in the new development trends of multiple neural network architecture, based on decision fusion. The most representative articles covering the area of melanoma detection based on neural networks, published in journals and impact conferences, were investigated between 2015 and 2021, focusing on the interval 2018–2021 as new trends. Additionally presented are the main databases and trends in their use in teaching neural networks to detect melanomas. Finally, a research agenda was highlighted to advance the field towards the new trends.

The incidence of melanoma cases continues to rise, underscoring the critical need for early detection and treatment. Recent studies highlight the significance of deep learning in melanoma detection, leading to improved accuracy. The field of computer-assisted detection is extensively explored along all lines, especially in the medical industry, as the benefit in this field is to save hu-man lives. In this domain, this direction must be maximally exploited and introduced into routine controls to improve patient prognosis, disease prevention, reduce treatment costs, improve population management, and improve patient empowerment. All these new aspects were taken into consideration to implement an EHR system with an automated melanoma detection system. The first step, as presented in this paper, is to build a system based on the fusion of decisions from multiple neural networks, such as DarkNet-53, DenseNet-201, GoogLeNet, Inception-V3, InceptionResNet-V2, ResNet-50, ResNet-101, and compare this classifier with four other applications: Google Teachable Machine, Microsoft Azure Machine Learning, Google Vertex AI, and SalesForce Einstein Vision based on the F1 score for further integration into an EHR platform. We trained all models on two databases, ISIC 2020 and DermIS, to also test their adaptability to a wide range of images. Comparisons with state-of-the-art research and existing applications confirm the promising performance of the proposed system.