Arjun Kafle

Dr. Arjun Kafle

Chemistry, Benedict College, Columbia, Connecticut, USA
orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 February 2014 in Organic Letters
Verified
Journal Article
Closed access
SGSantosh K. Gurung
Santosh K. Gurung
STSurendra Thapa
Surendra Thapa
Arjun KafleArjun Kafle
Arjun Kafle
DDDiane Dickie
Diane Dickie
RGRamesh Giri
Ramesh Giri

30 April 2014 in Advanced Synthesis & Catalysis
Verified
Journal Article
Closed access
PDF file
RGRamesh Giri
Ramesh Giri
STSurendra Thapa
Surendra Thapa
Arjun KafleArjun Kafle
Arjun Kafle

28 May 2015 in Angewandte Chemie International Edition
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Journal Article
Closed access
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STSurendra Thapa
Surendra Thapa
Arjun KafleArjun Kafle
Arjun Kafle
SGSantosh K. Gurung
Santosh K. Gurung
AMAdam Montoya
Adam Montoya
PRPatrick Riedel
Patrick Riedel
RGRamesh Giri
Ramesh Giri

1 November 2016 in Canadian Journal of Chemistry
Verified
Journal Article
Closed access
Arjun KafleArjun Kafle
Arjun Kafle
JLJun Liu
Jun Liu
LCLina Cui
Lina Cui
This review covers a special topic in carbohydrate chemistry — solvent effects on the stereoselectivity of glycosylation reactions. Obtaining highly stereoselective glycosidic linkages is one of the most challenging tasks in organic synthesis, as it is affected by various controlling factors. One of the least understood factors is the effect of solvents. We have described the known solvent effects while providing both general rules and specific examples. We hope this review will not only help fellow researchers understand the known aspects of solvent effects and use that in their experiments, but moreover, we expect that more studies on this topic will be started and continued to expand our understanding of the mechanistic aspects of solvent effects in glycosylation reactions.

22 December 2020 in RSC Advances
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Journal Article
Open access
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Arjun KafleArjun Kafle
Arjun Kafle
SBShrijana Bhattarai
Shrijana Bhattarai
Justin MillerJustin Miller
Justin Miller
Scott HandyScott Handy
Scott Handy
Hydrogen sulfide detection and sensing is an area of interest from both an environmental and a biological perspective. While many methods are currently available, the most sensitive and biologically applicable ones are fluorescence based. In general, these fluorescent probes are based upon large, high-molecular weight, well-characterized fluorescent scaffolds that are synthetically demanding to prepare and difficult to tune and modify. In this study, we have reported a new reduction-based, rationally designed and synthesized turn-on fluorescent probe (Z)-2-(4′-azidobenzylidene)-5-fluorobenzofuran-3(2H)-one (6g) utilizing a low molecular weight aurone fluorophore. During these studies, the modular nature of the synthesis was used to quickly overcome problems with solubility, overlap of excitation of the probe and reduced product, and rate of reaction, resulting in a final compound that is efficient and sensitive for the detection of hydrogen sulfide. The limitation of slow reaction and the reduced fluorescence in a biologically relevent medium was solved by employing cationic surfactant cetyltrimethyl ammonium bromide (CTAB). The probe features a high fluorescence enhancement, fast response (10–30 min), and good sensitivity (1 μm) and selectivity for hydrogen sulfide.

20 October 2020 in Chemical Science
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Journal Article
Open access
PDF file
JLJun Liu
Jun Liu
KSKelton A. Schleyer
Kelton A. Schleyer
TBTyrel L. Bryan
Tyrel L. Bryan
CXChangjian Xie
Changjian Xie
GSGustavo Seabra
Gustavo Seabra
LCLina Cui
Lina Cui
Heparanase (HPA) is a critical enzyme involved in the remodeling of the extracellular matrix (ECM), and its elevated expression has been linked with diseases such as various types of cancer and inflammation. The detection of heparanase enzymatic activity holds tremendous value in the study of the cellular microenvironment, and search of molecular therapeutics targeting heparanase, however, no structurally defined probes are available for the detection of heparanase activity. Here we present the development of the first ultrasensitive fluorogenic small-molecule probe for heparanase enzymatic activity via tuning the electronic effect of the substrate. The probe exhibits a 756-fold fluorescence turn-on response in the presence of human heparanase, allowing one-step detection of heparanase activity in real-time with a picomolar detection limit. The high sensitivity and robustness of the probe are exemplified in a high-throughput screening assay for heparanase inhibitors.