Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a universal method for the quantitative analysis of small molecular drugs in therapeutic drug monitoring (TDM). Alternatively, liquid chromatography-miniature mass spectrometry (LC-Mini MS) is a simple operating technique for quantitative analysis. However, the wide chromatographic peaks and long retention times of TDM samples using the LC-Mini MS system deteriorated the accuracy and efficiency of quantitative analysis. Here, an optimized electrospray ionization (ESI) interface setup with a splitter valve and a capillary needle (I.D. 30 μm and O.D. 150 μm) of the LC-Mini MS system was acquired. The chromatographic peaks were narrower and smoother and the retention time was shorter for TDM compounds. Furthermore, a quantitative analysis method for risperidone and the active metabolite 9-hydroxyrisperidone in plasma was developed based on this optimal LC-Mini MS setup. The results showed that the calibration curves of risperidone and 9-hydroxyrisperidone had good linear ranges of 2–100 ng mL⁻¹ (R² = 0.9931) and 2–100 ng mL⁻¹ (R² = 0.9915), respectively. Finally, the matrix effects, recoveries and stability of risperidone and 9-hydroxyrisperidone samples were analyzed. The results satisfied the requirements of quantitative validation in routine TDM procedures.

Coherent frequency agile radar has a strong anti-jamming ability, but it may encounter difficulty in computational effort while reconstructing target using compressed sensing. In this paper, an acceleration method and implementation of Orthogonal Matching Pursuit algorithm (OMP) based on CUDA are developed to meet the needs of real-time application of sparse reconstruction algorithm of coherent frequency agile radar target. The algorithms are tested on a computer with a NVIDIA Rtx2070 Super GPU and an Inter-i5-10400f CPU. Computational results indicate that the proposed parallelization method has a good acceleration effect on compressed sensing reconstruction calculation.

In order to deeply understand the status of ideological and political research on experimental courses in colleges and universities, the relevant literature collected by China National Knowledge Infrastructure (CNKI) was taken as the research object, and the analysis was carried out by using CiteSpace software. The results show that research authors of ideological and political education in experimental courses have not yet formed cross-regional cooperation, and there is no core author. The ideological and political construction of experimental courses mainly focuses on experimental courses such as medicine, chemistry, and physics. The research focus on ideological and political education in experimental courses focuses on the concept of educating people, the construction of teaching systems, teaching modes, and the combination of new experimental teaching methods and ideological and political elements. The ideological and political education of experimental courses needs more attention and support from colleges and universities.