Although considerable efforts have been made to understand the neural underpinnings of (state) reactive aggression, which is triggered by provocation or perceived threat, little is known about the neural correlates of proactive aggression, which is driven by instrumental motivations to obtain personal gains through aggressive means and which varies dramatically across individuals in terms of tendency of appealing to such means. Here, by combining structural (grey matter density, GMD) and functional (resting-state functional connection, RSFC) fMRI, we investigated brain structures and functional networks related to trait proactive aggression. We found that individual differences in trait proactive aggression were positively associated with GMD in bilateral dorsolateral prefrontal cortex (DLPFC) and negatively correlated with GMD in posterior cingulate cortex (PCC); they were also negatively correlated with the strength of functional connectivity between left PCC and other brain regions, including right DLPFC, right IPL, right MPFC/ACC, and bilateral precuneus. These findings shed light on the differential brain bases of proactive and reactive aggressions and suggested the neural underpinnings of proactive aggression.

Angry rumination is a common mental phenomenon which may lead to negative social behaviors such as aggression. Although numerous neuroimaging studies have focused on brain area activation during angry rumination, to our knowledge no study has examined the neuroanatomical and cognitive mechanisms of this process. In this study, we conducted a voxel-based morphometry analysis, using a region of interest analysis to identify the structural and cognitive mechanisms underlying individual differences in trait angry rumination (as measured by the Angry Rumination Scale) in a sample of 82 undergraduate students. We found that angry rumination was positively correlated with gray matter density in the left middle frontal gyrus (left-MFG), which is implicated in inhibition control, working memory, and emotional regulation. The mediation analysis further revealed that hostile attribution bias (as measured by the Social Information Processing–Attribution Bias Questionnaire) acted as a cognitive mechanism underlying the positive association between the left-MFG gray matter density and trait angry rumination. These findings suggest that hostile attribution bias may contribute to trait angry rumination, while the left-MFG may play an important role in the development of hostile attribution bias and trait angry rumination. The study reveals the brain mechanisms of trait angry rumination and plays a role in revealing the cognitive mechanisms of the development of trait angry rumination.

Angry rumination and hostile attribution bias are important cognitive factors of aggression. Although prior theoretical models of aggression suggest that aggressive cognitive factors may influence each other, there are no studies examining the longitudinal relationship between angry rumination and hostile attribution bias. The present study used cross-lagged structural equation modeling to explore the longitudinal mutual relationship between hostile attribution bias and angry rumination; 941 undergraduate students (38.5% male) completed questionnaires assessing the variables at two time points. The results indicate that hostile attribution bias showed a small but statistically significant effect on angry rumination 6 months later, and angry rumination showed a quite small but marginally significant effect on hostile attribution bias across time. The present study supports the idea that hostile attribution bias influences angry rumination, and argue that the relationship between angry rumination and hostile attribution bias may be mutual. Additionally, the results suggest that there may be a causal relation of different aggression-related cognitive factors.