Chiara Longo

Dr. Chiara Longo


Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 September 2024 in Polish Journal of Radiology
Verified
Journal Article
Open access
GFGiovanni Foti
Giovanni Foti
CLChiara Longo
Chiara Longo
Magnetic resonance imaging (MRI) is a powerful imaging modality, but one of its drawbacks is its relatively long scanning time to acquire high-resolution images. Reducing the scanning time has become a critical area of focus in MRI, aiming to enhance patient comfort, reduce motion artifacts, and increase MRI throughput. In the past 5 years, artificial intelligence (AI)-based algorithms, particularly deep learning models, have been developed to reconstruct high-resolution images from significantly fewer data points. These new techniques significantly enhance MRI efficiency, improve patient comfort and lower patient motion artifacts. Improving MRI throughput with lower scanning duration increases accessibility, potentially reducing the need for additional MRI machines and associated costs. Several fields can benefit from shortened protocols, especially for routine exams. In oncologic imaging, faster MRI scans can facilitate more regular monitoring of cancer patients. In patients suffering from neurological disorders, rapid brain imaging can aid in the quick assessment of conditions like stroke, multiple sclerosis, and epilepsy, improving patient outcomes. In chronic inflammatory disease, faster imaging may help in reducing the interval between imaging to better check therapy outcomes. Additionally, reducing scanning time could effectively help MRI to play a role in emergency medicine and acute conditions such as trauma or acute ischaemic stroke. The purpose of this paper is to describe and discuss the advantages and disadvantages of introducing deep learning reconstruction techniques to reduce MRI scanning times in clinical practice.

23 February 2024 in Tomography
Verified
Journal Article
Open access
PDF file
GFGiovanni Foti
Giovanni Foti
GAGiorgio Ascenti
Giorgio Ascenti
AAAndrea Agostini
Andrea Agostini
CLChiara Longo
Chiara Longo
FLFabio Lombardo
Fabio Lombardo
SGStefania Gori
Stefania Gori
Dual-energy CT (DECT) is an innovative technology that is increasingly widespread in clinical practice. DECT allows for tissue characterization beyond that of conventional CT as imaging is performed using different energy spectra that can help differentiate tissues based on their specific attenuation properties at different X-ray energies. The most employed post-processing applications of DECT include virtual monoenergetic images (VMIs), iodine density maps, virtual non-contrast images (VNC), and virtual non-calcium (VNCa) for bone marrow edema (BME) detection. The diverse array of images obtained through DECT acquisitions offers numerous benefits, including enhanced lesion detection and characterization, precise determination of material composition, decreased iodine dose, and reduced artifacts. These versatile applications play an increasingly significant role in tumor assessment and oncologic imaging, encompassing the diagnosis of primary tumors, local and metastatic staging, post-therapy evaluation, and complication management. This article provides a comprehensive review of the principal applications and post-processing techniques of DECT, with a specific focus on its utility in managing oncologic patients.

13 February 2023 in Diagnostics
Verified
Journal Article
Open access
PDF file
GFGiovanni Foti
Giovanni Foti
CLChiara Longo
Chiara Longo
CSClaudia Sorgato
Claudia Sorgato
EOEugenio Simone Oliboni
Eugenio Simone Oliboni
CMCristina Mazzi
Cristina Mazzi
Stefania MaroccoStefania Marocco
Stefania Marocco
Background: MRI is the preferred imaging technique for the identification of osteomyelitis. The key element for diagnosis is the presence of bone marrow edema (BME). Dual-energy CT (DECT) is an alternative tool which is able to identify BME in the lower limb. Purpose: To compare the diagnostic performance of DECT and MRI for osteomyelitis, using clinical, microbiological, and imaging data as reference standards. Materials and Methods: This prospective single-center study enrolled consecutive patients with suspected bone infections undergoing DECT and MRI imaging from December 2020 to June 2022. Four blinded radiologists with various experience levels (range of 3-21 years) evaluated the imaging findings. Osteomyelitis was diagnosed in the presence of BMEs, abscesses, sinus tracts, bone reabsorption, or gaseous elements. The sensitivity, specificity, and AUC values of each method were determined and compared using a multi-reader multi-case analysis. A p value < 0.05 was considered significant. Results: In total, 44 study participants (mean age 62.5 years ± 16.5 [SD], 32 men) were evaluated. Osteomyelitis was diagnosed in 32 participants. For the MRI, the mean sensitivity and specificity were 89.1% and 87.5%, while for the DECT they were 89.0% and 72.9%, respectively. The DECT demonstrated a good diagnostic performance (AUC = 0.88), compared with the MRI (AUC = 0.92) (p = 0.12). When considering each imaging finding alone, the best accuracy was achieved by considering BME (AUC for DECT 0.85 versus AUC of MRI of 0.93, with p = 0.07), followed by the presence of bone erosions (AUC 0.77 for DECT and 0.53 for MRI, with p = 0.02). The inter-reader agreement of the DECT (k = 88) was similar to that of the MRI (k = 90). Conclusion: Dual-energy CT demonstrated a good diagnostic performance in detecting osteomyelitis.

1 March 2023 in Radiology
Verified
Journal Article
Closed access
GFGiovanni Foti
Giovanni Foti
CLChiara Longo
Chiara Longo
MDMirko D’oNofrio
Mirko D’oNofrio
SNSimone Natali
Simone Natali
GPGianluca Piovan
Gianluca Piovan
CZClaudio Zorzi
Claudio Zorzi
Dual-energy CT had generally better diagnostic performance and interreader reproducibility to identify loosening of tibial and femoral components in painful total knee prosthesis compared with sing... Background Dual-energy CT (DECT) is an alternative to radiography and single-energy CT (SECT) for detecting prosthesis-related complications. Purpose To compare the diagnostic performance of DECT, ...

1 November 2024 in Radiology
Verified
Journal Article
Closed access
GFGiovanni Foti
Giovanni Foti
LSLorenza Sanfilippo
Lorenza Sanfilippo
CLChiara Longo
Chiara Longo
EOEugenio Oliboni
Eugenio Oliboni
NSNicoletta De Santis
Nicoletta De Santis
RFRoberto Filippini
Roberto Filippini
Dual-energy CT helped to accurately diagnose bone stress fractures and stress reactions of the lower limb (leg, ankle, and foot) using MRI as the reference standard.

7 June 2020 in Cancers
Verified
Journal Article
Open access
PDF file
ABAlessandro Beleù
Alessandro Beleù
GRGiulio Rizzo
Giulio Rizzo
RRRiccardo De Robertis
Riccardo De Robertis
ADAlessandro Drudi
Alessandro Drudi
GAGregorio Aluffi
Gregorio Aluffi
Mirko D'OnofrioMirko D'Onofrio
Mirko D'Onofrio
Pancreatic neuroendocrine tumors (p-NETs) are a rare group of neoplasms that often present with liver metastases. Histological characteristics, metabolic behavior, and liver tumor burden (LTB) are important prognostic factors. In this study, the usefulness of texture analysis of liver metastases in evaluating the biological aggressiveness of p-NETs was assessed. Fifty-six patients with liver metastases from p-NET were retrospectively enrolled. Qualitative and quantitative CT features of LTB were evaluated. Histogram-derived parameters of liver metastases were calculated and correlated with the tumor grade (G) and 18F-fluorodeoxyglucose (18F-FDG) standardized uptake value (SUV). Arterial relative enhancement was inversely related with G (−0.37, p = 0.006). Different metastatic spread patterns of LTB were not associated with histological grade. Arterialentropy was significantly correlated to G (−0.368, p = 0.038) and to Ki67 percentage (−0.421, p = 0.018). The ROC curve for the Arterialentropy reported an area under the curve (AUC) of 0.736 (95% confidence interval 0.545–0.928, p = 0.035) in the identification of G1–2 tumors. Arterialuniformity values were correlated to G (0.346, p = 0.005) and Ki67 levels (0.383, p = 0.033). Arterialentropy values were directly correlated with the SUV (0.449, p = 0.047) which was inversely correlated with Arterialuniformity (−0.499, p = 0.025). Skewness and kurtosis reported no significant correlations. In conclusion, histogram-derived parameters may predict adverse histological features and metabolic behavior of p-NET liver metastases.