While previous studies have investigated the pathophysiology, epidemiology, and risk factors of invasive pulmonary aspergillosis (IPA), research trends and hotspots on this topic remain relatively unexplored. This study aims to develop a visual knowledge map using bibliometric analysis to identify research hotspots and predict future trends in IPA research. A systematic search was conducted on the Web of Science Core Collection for articles published between January 1, 2000, and March 31, 2024. Tools such as CiteSpace and VOSviewer were used to analyze annual publication trends, contributions by countries, institutions, journals, authors, and references, as well as key research areas to identify current hotspots and future directions. A total of 4058 articles were included, representing contributions from 3409 institutions across 749 journals and 214 countries or regions. The United States published the most articles (1312) and emerged as the most influential country in this field. Medical Mycology published the highest number of articles (206), while Clinical Infectious Diseases was the most cited journal (27,450 citations). Keyword clustering revealed 4 major themes: diagnostics (e.g., galactomannan assays), clinical management (e.g., antifungal therapy), at-risk populations (e.g., transplant recipients), and emerging trends (e.g., COVID-19-associated IPA). Temporal analysis identified 3 distinct research phases: early phase (2000–2007): focus on bone marrow transplantation and diagnostic methods. mid-phase (2008–2018): emphasis on clinical guidelines and epidemiological studies. Recent phase (2019–2024): shift toward COVID-19-associated IPA and its impacts. By applying bibliometric methods to analyze IPA research, this study identifies key authors, countries, institutions, and journals in terms of collaboration and influence. It enhances the understanding of research hotspots in the field and provides insights into potential future collaborations and research directions.

Background: The rise of antimicrobial resistance and the COVID-19 pandemic highlight the limitations of traditional therapies. Small interfering RNA (siRNA) therapeutics, which utilize RNA interference for targeted gene silencing, present a promising approach to combating microbial infections. However, research in this area remains fragmented. This study employs a comprehensive bibliometric analysis to chart research trends and inform future directions. Methods: A total of 8,426 publications from the Web of Science Core Collection (2001–2025) were analyzed using CiteSpace and VOSviewer software to examine annual publication trends, geographic and institutional contributions, author networks, journal impacts, and keyword evolution. Data extraction focused on English-language articles. Results: The publication trends for siRNA therapeutics in microbial infections have evolved in three phases: rapid growth, stabilization at a peak, and subsequent cyclical fluctuations. Research contributions spanned 99 countries and regions, with 5,564 institutions and 1,234 journals involved. China (2,849 publications) and the United States (2,820 publications) led in publication volume. While the United States maintained dominance in academic influence and collaboration, China has steadily increased its research output in this area. The Journal of Virology emerged as the leading journal in terms of both productivity and citation impact. Key research areas include delivery systems, target selection, manufacturing technologies, antiviral therapeutics, and combination therapies. The field has shifted from basic mechanistic studies to clinical applications, with future research poised to focus on organ-specific delivery beyond the liver, exploration of diverse administration routes, integration of artificial intelligence-driven strategies, and enhanced global collaboration. Conclusion: This bibliometric analysis offers a comprehensive overview of siRNA therapeutics for microbial infections, highlighting collaboration networks and academic influence across authors, countries, institutions, and journals. The study provides valuable insights into current research trends and serves as a foundational reference for guiding future collaborative efforts and innovations in this field.