Line-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Comparing LC-OCT diagnostic performances with those of dermoscopy, histopathological examination was used as a gold standard. For every study endpoint, the diagnostic ability of LC-OCT revealed superiority over the dermoscopic examination. In particular, a significant increase in specificity was observed. Sensitivity, specificity, and diagnostic accuracy of dermoscopy and LC-OCT for the diagnosis of malignancy were, respectively, 0.97 (CI 0.94–0.99), 0.43 (CI 0.36–0.51), and 0.77 (CI 0.72–0.81) for dermoscopy and 0.99 (CI 0.97–1.00), 0.90 (CI 0.84–0.94), and 0.96 (CI 0.93–0.97) for LC-OCT. The positive predictive value (PPV) resulted in 0.74 (CI 0.69–0.78) for dermoscopy and 0.94 (CI 0.91–0.97) for LC-OCT, and the negative predictive value (NPV) was 0.89 (CI 0.81–0.95) for dermoscopy and 0.98 (CI 0.95–1.00) for LC-OCT. Finally, our real-life study showed a potentially important role of LC-OCT in the non-invasive diagnosis of NMSCs, especially BCC. The real-time imaging technique could spare unnecessary biopsies with an increased sensitivity, a much higher specificity, and better accuracy than clinical assessment with dermoscopy alone.

Article: Inflammatory and infectious skin diseases in line-field confocal optical coherence tomography: state of the art - Italian Journal of Dermatology and Venereology 2023 June;158(3):190-6 - Minerva Medica - Journals

Citation: Cortonesi G, Donelli C, Rubegni P, Miracco C, Cinotti E. Non-invasive Imaging Techniques for the Diagnosis of Clear Cell Acanthomas: Dermoscopy, Reflectance Confocal Microscopy and Line-Field Confocal Optical Coherence Tomography. Dermatol Pract Concept. 2023;13(4):e2023231. DOI: https://doi.org/10.5826/dpc.1304a231 Accepted: April 20, 2023; Published: October 2023 Copyright: ©2023 Cortonesi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding author: Carolina Donelli, MD, Dermatology Section, Santa Maria Alle Scotte Hospital Viale Bracci 16, 53100 Siena, Italy Email: carolina.donelli@gmail.com This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Citation: Cortonesi G, Donelli C, Rubegni P, Trovato E. Combination of Fractional CO2 Laser Therapy and Photodynamic Therapy for the Treatment of Plasma Cell Cheilitis. Dermatol Pract Concept. 2024;14(1):e2024004. DOI: https://doi.org/10.5826/dpc.1401a4 Accepted: July 6, 2023; Published: January 2024 Copyright: ©2024 Cortonesi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding author: Carolina Donelli, MD, Dermatology Section, Santa Maria Alle Scotte Hospital, Viale Bracci 16, 53100 Siena, Italy. Email: carolina.donelli@gmail.com Keywords : plasma-cell, cheilitis, laser This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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